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Fusion gene ID: 35027 |
FusionGeneSummary for SMYD2_PTP4A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMYD2_PTP4A1 | Fusion gene ID: 35027 | Hgene | Tgene | Gene symbol | SMYD2 | PTP4A1 | Gene ID | 56950 | 7803 |
| Gene name | SET and MYND domain containing 2 | protein tyrosine phosphatase type IVA, member 1 | |
| Synonyms | HSKM-B|KMT3C|ZMYND14 | HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1 | |
| Cytomap | 1q32.3 | 6q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-lysine methyltransferase SMYD2SET and MYND domain-containing protein 2histone methyltransferase SMYD2lysine N-methyltransferase 3Czinc finger, MYND domain containing 14 | protein tyrosine phosphatase type IVA 1PVT1/PTP4A1 fusionphosphatase of regenerating liver 1protein tyrosine phosphatase type IVA protein 1protein-tyrosine phosphatase 4a1protein-tyrosine phosphatase of regenerating liver 1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9NRG4 | Q93096 | |
| Ensembl transtripts involved in fusion gene | ENST00000491455, ENST00000415093, ENST00000366957, | ENST00000370651, ENST00000370650, ENST00000578299, ENST00000473334, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 4 X 2 X 3=24 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SMYD2 [Title/Abstract] AND PTP4A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMYD2 | GO:0018026 | peptidyl-lysine monomethylation | 17108971|20870719 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-AAMT-01A | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000491455 | ENST00000370651 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 3UTR-5UTR | ENST00000491455 | ENST00000370650 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 3UTR-5UTR | ENST00000491455 | ENST00000578299 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 3UTR-3UTR | ENST00000491455 | ENST00000473334 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 5CDS-5UTR | ENST00000415093 | ENST00000370651 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 5CDS-5UTR | ENST00000415093 | ENST00000370650 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 5CDS-5UTR | ENST00000415093 | ENST00000578299 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 5CDS-3UTR | ENST00000415093 | ENST00000473334 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 5CDS-5UTR | ENST00000366957 | ENST00000370651 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 5CDS-5UTR | ENST00000366957 | ENST00000370650 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 5CDS-5UTR | ENST00000366957 | ENST00000578299 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
| 5CDS-3UTR | ENST00000366957 | ENST00000473334 | SMYD2 | chr1 | 214454770 | + | PTP4A1 | chr6 | 64286341 | + |
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FusionProtFeatures for SMYD2_PTP4A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMYD2 | PTP4A1 |