|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 35008 |
FusionGeneSummary for SMURF2P1_GOSR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMURF2P1_GOSR1 | Fusion gene ID: 35008 | Hgene | Tgene | Gene symbol | SMURF2P1 | GOSR1 | Gene ID | 107133516 | 9527 |
| Gene name | SMAD specific E3 ubiquitin protein ligase 2 pseudogene 1 | golgi SNAP receptor complex member 1 | |
| Synonyms | - | GOLIM2|GOS-28|GOS28|GOS28/P28|GS28|P28 | |
| Cytomap | 17q11.2 | 17q11.2 | |
| Type of gene | pseudo | protein-coding | |
| Description | - | Golgi SNAP receptor complex member 128 kDa Golgi SNARE protein28 kDa cis-Golgi SNARE p28Golgi SNARE 28 kDacis-golgi SNAREgolgi integral membrane protein 2 | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | O95249 | ||
| Ensembl transtripts involved in fusion gene | ENST00000579301, | ENST00000225724, ENST00000451249, ENST00000467337, ENST00000581721, ENST00000579905, | |
| Fusion gene scores | * DoF score | 7 X 2 X 6=84 | 4 X 4 X 3=48 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SMURF2P1 [Title/Abstract] AND GOSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GOSR1 | GO:0042147 | retrograde transport, endosome to Golgi | 15215310 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-EY-A4KR-01A | SMURF2P1 | chr17 | 28937960 | + | GOSR1 | chr17 | 28837898 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000579301 | ENST00000225724 | SMURF2P1 | chr17 | 28937960 | + | GOSR1 | chr17 | 28837898 | + |
| 3UTR-3CDS | ENST00000579301 | ENST00000451249 | SMURF2P1 | chr17 | 28937960 | + | GOSR1 | chr17 | 28837898 | + |
| 3UTR-3CDS | ENST00000579301 | ENST00000467337 | SMURF2P1 | chr17 | 28937960 | + | GOSR1 | chr17 | 28837898 | + |
| 3UTR-intron | ENST00000579301 | ENST00000581721 | SMURF2P1 | chr17 | 28937960 | + | GOSR1 | chr17 | 28837898 | + |
| 3UTR-intron | ENST00000579301 | ENST00000579905 | SMURF2P1 | chr17 | 28937960 | + | GOSR1 | chr17 | 28837898 | + |
Top |
FusionProtFeatures for SMURF2P1_GOSR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMURF2P1 | GOSR1 |