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Fusion gene ID: 34993 |
FusionGeneSummary for SMURF1_DNAJC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMURF1_DNAJC2 | Fusion gene ID: 34993 | Hgene | Tgene | Gene symbol | SMURF1 | DNAJC2 | Gene ID | 57154 | 27000 |
| Gene name | SMAD specific E3 ubiquitin protein ligase 1 | DnaJ heat shock protein family (Hsp40) member C2 | |
| Synonyms | - | MPHOSPH11|MPP11|ZRF1|ZUO1 | |
| Cytomap | 7q22.1 | 7q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase SMURF1E3 ubiquitin ligase SMURF1HECT-type E3 ubiquitin transferase SMURF1Smad ubiquitination regulatory factor 1Smad-specific E3 ubiquitin ligase 1hSMURF1 | dnaJ homolog subfamily C member 2DnaJ (Hsp40) homolog, subfamily C, member 2M-phase phosphoprotein 11zuotin-related factor 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9HCE7 | Q99543 | |
| Ensembl transtripts involved in fusion gene | ENST00000361368, ENST00000361125, ENST00000480055, | ENST00000249270, ENST00000379263, ENST00000412522, | |
| Fusion gene scores | * DoF score | 16 X 5 X 12=960 | 3 X 4 X 2=24 |
| # samples | 15 | 2 | |
| ** MAII score | log2(15/960*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/24*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMURF1 [Title/Abstract] AND DNAJC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMURF1 | GO:0000209 | protein polyubiquitination | 19937093 |
| Hgene | SMURF1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 10458166|12151385|19937093 |
| Hgene | SMURF1 | GO:0006611 | protein export from nucleus | 11278251 |
| Hgene | SMURF1 | GO:0016567 | protein ubiquitination | 11278251 |
| Hgene | SMURF1 | GO:0030154 | cell differentiation | 10458166 |
| Hgene | SMURF1 | GO:0030509 | BMP signaling pathway | 21572392 |
| Hgene | SMURF1 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 11278251|12151385 |
| Hgene | SMURF1 | GO:0030514 | negative regulation of BMP signaling pathway | 27214554 |
| Hgene | SMURF1 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process | 11278251|12151385 |
| Hgene | SMURF1 | GO:0032801 | receptor catabolic process | 12151385 |
| Hgene | SMURF1 | GO:0034394 | protein localization to cell surface | 12151385 |
| Hgene | SMURF1 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 11278251 |
| Hgene | SMURF1 | GO:1903861 | positive regulation of dendrite extension | 23999003 |
| Tgene | DNAJC2 | GO:0045893 | positive regulation of transcription, DNA-templated | 21179169 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-49-AAR0-01A | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| TCGA | LD | LUAD | TCGA-49-AAR0-01A | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000361368 | ENST00000249270 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| Frame-shift | ENST00000361368 | ENST00000379263 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| Frame-shift | ENST00000361368 | ENST00000412522 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| Frame-shift | ENST00000361125 | ENST00000249270 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| Frame-shift | ENST00000361125 | ENST00000379263 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| Frame-shift | ENST00000361125 | ENST00000412522 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| intron-3CDS | ENST00000480055 | ENST00000249270 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| intron-3CDS | ENST00000480055 | ENST00000379263 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| intron-3CDS | ENST00000480055 | ENST00000412522 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982312 | - |
| Frame-shift | ENST00000361368 | ENST00000249270 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| Frame-shift | ENST00000361368 | ENST00000379263 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| Frame-shift | ENST00000361368 | ENST00000412522 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| Frame-shift | ENST00000361125 | ENST00000249270 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| Frame-shift | ENST00000361125 | ENST00000379263 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| Frame-shift | ENST00000361125 | ENST00000412522 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| intron-3CDS | ENST00000480055 | ENST00000249270 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| intron-3CDS | ENST00000480055 | ENST00000379263 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
| intron-3CDS | ENST00000480055 | ENST00000412522 | SMURF1 | chr7 | 98741349 | - | DNAJC2 | chr7 | 102982401 | - |
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FusionProtFeatures for SMURF1_DNAJC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMURF1 | DNAJC2 |