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Fusion gene ID: 34973 |
FusionGeneSummary for SMR3B_MYH9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMR3B_MYH9 | Fusion gene ID: 34973 | Hgene | Tgene | Gene symbol | SMR3B | MYH9 | Gene ID | 10879 | 4627 |
| Gene name | submaxillary gland androgen regulated protein 3B | myosin heavy chain 9 | |
| Synonyms | P-B|PBII|PRL3|PROL3|SMR1B | BDPLT6|DFNA17|EPSTS|FTNS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCA | |
| Cytomap | 4q13.3 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | submaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog B | myosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-A | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P02814 | P35579 | |
| Ensembl transtripts involved in fusion gene | ENST00000504825, ENST00000304915, | ENST00000216181, ENST00000475726, ENST00000401701, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 23 X 25 X 7=4025 |
| # samples | 2 | 28 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(28/4025*10)=-3.84549005094438 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMR3B [Title/Abstract] AND MYH9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MYH9 | GO:0001525 | angiogenesis | 16403913 |
| Tgene | MYH9 | GO:0006509 | membrane protein ectodomain proteolysis | 16186248 |
| Tgene | MYH9 | GO:0030048 | actin filament-based movement | 12237319|15845534 |
| Tgene | MYH9 | GO:0031032 | actomyosin structure organization | 24072716 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BX486673 | SMR3B | chr4 | 71255517 | + | MYH9 | chr22 | 36768443 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000504825 | ENST00000216181 | SMR3B | chr4 | 71255517 | + | MYH9 | chr22 | 36768443 | - |
| 5CDS-intron | ENST00000504825 | ENST00000475726 | SMR3B | chr4 | 71255517 | + | MYH9 | chr22 | 36768443 | - |
| 5CDS-intron | ENST00000504825 | ENST00000401701 | SMR3B | chr4 | 71255517 | + | MYH9 | chr22 | 36768443 | - |
| 5CDS-intron | ENST00000304915 | ENST00000216181 | SMR3B | chr4 | 71255517 | + | MYH9 | chr22 | 36768443 | - |
| 5CDS-intron | ENST00000304915 | ENST00000475726 | SMR3B | chr4 | 71255517 | + | MYH9 | chr22 | 36768443 | - |
| 5CDS-intron | ENST00000304915 | ENST00000401701 | SMR3B | chr4 | 71255517 | + | MYH9 | chr22 | 36768443 | - |
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FusionProtFeatures for SMR3B_MYH9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMR3B | MYH9 |