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Fusion gene ID: 34952 |
FusionGeneSummary for SMO_CAMK1D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMO_CAMK1D | Fusion gene ID: 34952 | Hgene | Tgene | Gene symbol | SMO | CAMK1D | Gene ID | 54498 | 57118 |
| Gene name | spermine oxidase | calcium/calmodulin dependent protein kinase ID | |
| Synonyms | C20orf16|PAO|PAO-1|PAO1|PAOH|PAOH1|SMO | CKLiK|CaM-K1|CaMKID | |
| Cytomap | 20p13 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | spermine oxidaseflavin containing amine oxidaseflavin-containing spermine oxidasepolyamine oxidase 1putative cyclin G1 interacting protein | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q99835 | Q8IU85 | |
| Ensembl transtripts involved in fusion gene | ENST00000249373, | ENST00000378847, ENST00000487696, ENST00000378845, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 8 X 9 X 6=432 |
| # samples | 7 | 10 | |
| ** MAII score | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMO [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMO | GO:0006598 | polyamine catabolic process | 12477380 |
| Tgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF876881 | SMO | chr7 | 128850907 | + | CAMK1D | chr10 | 12522173 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000249373 | ENST00000378847 | SMO | chr7 | 128850907 | + | CAMK1D | chr10 | 12522173 | - |
| 5CDS-intron | ENST00000249373 | ENST00000487696 | SMO | chr7 | 128850907 | + | CAMK1D | chr10 | 12522173 | - |
| 5CDS-intron | ENST00000249373 | ENST00000378845 | SMO | chr7 | 128850907 | + | CAMK1D | chr10 | 12522173 | - |
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FusionProtFeatures for SMO_CAMK1D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMO | CAMK1D |