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Fusion gene ID: 34930 |
FusionGeneSummary for SMIM15_ELOVL7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMIM15_ELOVL7 | Fusion gene ID: 34930 | Hgene | Tgene | Gene symbol | SMIM15 | ELOVL7 | Gene ID | 643155 | 79993 |
| Gene name | small integral membrane protein 15 | ELOVL fatty acid elongase 7 | |
| Synonyms | C5orf43 | - | |
| Cytomap | 5q12.1 | 5q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | small integral membrane protein 15UPF0542 protein C5orf43 | elongation of very long chain fatty acids protein 73-keto acyl-CoA synthase ELOVL7ELOVL FA elongase 7ELOVL family member 7, elongation of long chain fatty acidsvery long chain 3-ketoacyl-CoA synthase 7very long chain 3-oxoacyl-CoA synthase 7 | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | Q7Z3B0 | A1L3X0 | |
| Ensembl transtripts involved in fusion gene | ENST00000339020, ENST00000507416, | ENST00000508821, ENST00000425382, ENST00000438340, ENST00000505959, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 6=180 |
| # samples | 2 | 10 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(10/180*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMIM15 [Title/Abstract] AND ELOVL7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ELOVL7 | GO:0019367 | fatty acid elongation, saturated fatty acid | 19826053 |
| Tgene | ELOVL7 | GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 20937905 |
| Tgene | ELOVL7 | GO:0042761 | very long-chain fatty acid biosynthetic process | 19826053|20937905 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-UF-A7JD-01A | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000339020 | ENST00000508821 | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
| 5UTR-intron | ENST00000339020 | ENST00000425382 | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
| 5UTR-intron | ENST00000339020 | ENST00000438340 | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
| 5UTR-5UTR | ENST00000339020 | ENST00000505959 | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
| 5UTR-5UTR | ENST00000507416 | ENST00000508821 | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
| 5UTR-intron | ENST00000507416 | ENST00000425382 | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
| 5UTR-intron | ENST00000507416 | ENST00000438340 | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
| 5UTR-5UTR | ENST00000507416 | ENST00000505959 | SMIM15 | chr5 | 60456915 | - | ELOVL7 | chr5 | 60095057 | - |
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FusionProtFeatures for SMIM15_ELOVL7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMIM15 | ELOVL7 |