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Fusion gene ID: 34886 |
FusionGeneSummary for SMG1_CHP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMG1_CHP1 | Fusion gene ID: 34886 | Hgene | Tgene | Gene symbol | SMG1 | CHP1 | Gene ID | 23049 | 26973 |
| Gene name | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | cysteine and histidine rich domain containing 1 | |
| Synonyms | 61E3.4|ATX|LIP | CHP1 | |
| Cytomap | 16p12.3 | 11q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase SMG1PI-3-kinase-related kinase SMG-1SMG1 phosphatidylinositol 3-kinase-related kinaselambda-interacting proteinlambda/iota protein kinase C-interacting proteinsmg-1 homolog, phosphatidylinositol 3-kinase-related kinase | cysteine and histidine-rich domain-containing protein 1CHORD-containing protein 1CHP-1chord domain-containing protein 1cysteine and histidine-rich domain (CHORD) containing 1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96Q15 | Q99653 | |
| Ensembl transtripts involved in fusion gene | ENST00000389467, ENST00000446231, ENST00000565224, ENST00000567737, | ENST00000558351, ENST00000334660, ENST00000560397, | |
| Fusion gene scores | * DoF score | 14 X 10 X 7=980 | 5 X 5 X 2=50 |
| # samples | 16 | 10 | |
| ** MAII score | log2(16/980*10)=-2.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/50*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SMG1 [Title/Abstract] AND CHP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMG1 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 11544179 |
| Hgene | SMG1 | GO:0018105 | peptidyl-serine phosphorylation | 11544179|15175154 |
| Hgene | SMG1 | GO:0046777 | protein autophosphorylation | 11331269|11544179 |
| Hgene | SMG1 | GO:0046854 | phosphatidylinositol phosphorylation | 11331269 |
| Hgene | SMG1 | GO:2001020 | regulation of response to DNA damage stimulus | 15175154 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE615097 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + | ||
| ChiTaRS3.1 | BE616436 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000389467 | ENST00000558351 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-3UTR | ENST00000389467 | ENST00000334660 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-intron | ENST00000389467 | ENST00000560397 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-intron | ENST00000446231 | ENST00000558351 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-3UTR | ENST00000446231 | ENST00000334660 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-intron | ENST00000446231 | ENST00000560397 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-intron | ENST00000565224 | ENST00000558351 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-3UTR | ENST00000565224 | ENST00000334660 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-intron | ENST00000565224 | ENST00000560397 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-intron | ENST00000567737 | ENST00000558351 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-3UTR | ENST00000567737 | ENST00000334660 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
| intron-intron | ENST00000567737 | ENST00000560397 | SMG1 | chr16 | 18819376 | - | CHP1 | chr15 | 41573322 | + |
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FusionProtFeatures for SMG1_CHP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMG1 | CHP1 |