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Fusion gene ID: 34846 |
FusionGeneSummary for SMARCD3_NPIPB7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMARCD3_NPIPB7 | Fusion gene ID: 34846 | Hgene | Tgene | Gene symbol | SMARCD3 | NPIPB7 | Gene ID | 6604 | 440350 |
| Gene name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | nuclear pore complex interacting protein family member B7 | |
| Synonyms | BAF60C|CRACD3|Rsc6p | A-575C2.4|A-761H5.5|NPIPL1 | |
| Cytomap | 7q36.1 | 16p12.1 | |
| Type of gene | protein-coding | pseudo | |
| Description | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 360 kDa BRG-1/Brm-associated factor subunit CBRG1-associated factor 60CSWI/SNF complex 60 kDa subunit CSwp73-like proteinchromatin remodeling complex BAF60C s | nuclear pore complex-interacting protein-like 1 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q6STE5 | O75200 | |
| Ensembl transtripts involved in fusion gene | ENST00000262188, ENST00000392811, ENST00000356800, ENST00000477169, | ENST00000452313, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 16 X 18 X 1=288 |
| # samples | 3 | 19 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/288*10)=-0.600069393111365 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMARCD3 [Title/Abstract] AND NPIPB7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMARCD3 | GO:0002052 | positive regulation of neuroblast proliferation | 18816825 |
| Hgene | SMARCD3 | GO:0006337 | nucleosome disassembly | 8895581 |
| Hgene | SMARCD3 | GO:0006338 | chromatin remodeling | 11726552 |
| Hgene | SMARCD3 | GO:0006351 | transcription, DNA-templated | 14701856 |
| Hgene | SMARCD3 | GO:0045893 | positive regulation of transcription, DNA-templated | 14701856 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP276382 | SMARCD3 | chr7 | 150942569 | - | NPIPB7 | chr16 | 28592375 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000262188 | ENST00000452313 | SMARCD3 | chr7 | 150942569 | - | NPIPB7 | chr16 | 28592375 | + |
| intron-intron | ENST00000392811 | ENST00000452313 | SMARCD3 | chr7 | 150942569 | - | NPIPB7 | chr16 | 28592375 | + |
| intron-intron | ENST00000356800 | ENST00000452313 | SMARCD3 | chr7 | 150942569 | - | NPIPB7 | chr16 | 28592375 | + |
| intron-intron | ENST00000477169 | ENST00000452313 | SMARCD3 | chr7 | 150942569 | - | NPIPB7 | chr16 | 28592375 | + |
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FusionProtFeatures for SMARCD3_NPIPB7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMARCD3 | NPIPB7 |