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Fusion gene ID: 34703 |
FusionGeneSummary for SLMAP_FAF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLMAP_FAF1 | Fusion gene ID: 34703 | Hgene | Tgene | Gene symbol | SLMAP | FAF1 | Gene ID | 7871 | 11124 |
| Gene name | sarcolemma associated protein | Fas associated factor 1 | |
| Synonyms | SLAP | CGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1 | |
| Cytomap | 3p14.3 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sarcolemmal membrane-associated protein | FAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3A | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q14BN4 | Q9UNN5 | |
| Ensembl transtripts involved in fusion gene | ENST00000295951, ENST00000416870, ENST00000295952, ENST00000383718, ENST00000428312, ENST00000449503, ENST00000472546, ENST00000442599, ENST00000495364, ENST00000494088, | ENST00000396153, ENST00000371778, ENST00000545823, ENST00000472808, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 17 X 15 X 9=2295 |
| # samples | 5 | 22 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2295*10)=-3.38291872477651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLMAP [Title/Abstract] AND FAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FAF1 | GO:0010942 | positive regulation of cell death | 15596450 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A4OF-01A | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000295951 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000295951 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000295951 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000295951 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000416870 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000416870 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000416870 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000416870 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000295952 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000295952 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000295952 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000295952 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-3CDS | ENST00000383718 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-3CDS | ENST00000383718 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-intron | ENST00000383718 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-intron | ENST00000383718 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000428312 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000428312 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000428312 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000428312 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000449503 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000449503 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000449503 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000449503 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-3CDS | ENST00000472546 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-3CDS | ENST00000472546 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-intron | ENST00000472546 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-intron | ENST00000472546 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-3CDS | ENST00000442599 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-3CDS | ENST00000442599 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-intron | ENST00000442599 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| intron-intron | ENST00000442599 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000495364 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000495364 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000495364 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000495364 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000494088 | ENST00000396153 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| Frame-shift | ENST00000494088 | ENST00000371778 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000494088 | ENST00000545823 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
| 5CDS-intron | ENST00000494088 | ENST00000472808 | SLMAP | chr3 | 57894877 | + | FAF1 | chr1 | 51267349 | - |
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FusionProtFeatures for SLMAP_FAF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLMAP | FAF1 |