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Fusion gene ID: 3469 |
FusionGeneSummary for ATP6V1C2_EIF4A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP6V1C2_EIF4A2 | Fusion gene ID: 3469 | Hgene | Tgene | Gene symbol | ATP6V1C2 | EIF4A2 | Gene ID | 245973 | 1974 |
| Gene name | ATPase H+ transporting V1 subunit C2 | eukaryotic translation initiation factor 4A2 | |
| Synonyms | ATP6C2|VMA5 | BM-010|DDX2B|EIF4A|EIF4F|eIF-4A-II|eIF4A-II | |
| Cytomap | - | 3q27.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | V-type proton ATPase subunit C 2ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2V-ATPase C2 subunitvacuolar proton pump subunit C 2 | eukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8NEY4 | Q14240 | |
| Ensembl transtripts involved in fusion gene | ENST00000272238, ENST00000381661, | ENST00000323963, ENST00000440191, ENST00000356531, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 7 X 8 X 3=168 |
| # samples | 5 | 11 | |
| ** MAII score | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/168*10)=-0.610957709254101 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATP6V1C2 [Title/Abstract] AND EIF4A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | EIF4A2 | GO:1900260 | negative regulation of RNA-directed 5'-3' RNA polymerase activity | 11922617 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI810008 | ATP6V1C2 | chr2 | 10923658 | + | EIF4A2 | chr3 | 186506831 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000272238 | ENST00000323963 | ATP6V1C2 | chr2 | 10923658 | + | EIF4A2 | chr3 | 186506831 | - |
| intron-intron | ENST00000272238 | ENST00000440191 | ATP6V1C2 | chr2 | 10923658 | + | EIF4A2 | chr3 | 186506831 | - |
| intron-intron | ENST00000272238 | ENST00000356531 | ATP6V1C2 | chr2 | 10923658 | + | EIF4A2 | chr3 | 186506831 | - |
| 3UTR-intron | ENST00000381661 | ENST00000323963 | ATP6V1C2 | chr2 | 10923658 | + | EIF4A2 | chr3 | 186506831 | - |
| 3UTR-intron | ENST00000381661 | ENST00000440191 | ATP6V1C2 | chr2 | 10923658 | + | EIF4A2 | chr3 | 186506831 | - |
| 3UTR-intron | ENST00000381661 | ENST00000356531 | ATP6V1C2 | chr2 | 10923658 | + | EIF4A2 | chr3 | 186506831 | - |
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FusionProtFeatures for ATP6V1C2_EIF4A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP6V1C2 | EIF4A2 |