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Fusion gene ID: 34675 |
FusionGeneSummary for SLFN11_CPE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLFN11_CPE | Fusion gene ID: 34675 | Hgene | Tgene | Gene symbol | SLFN11 | CPE | Gene ID | 91607 | 1363 |
| Gene name | schlafen family member 11 | carboxypeptidase E | |
| Synonyms | SLFN8/9 | CPH | |
| Cytomap | 17q12 | 4q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | schlafen family member 11 | carboxypeptidase Ecarboxypeptidase Hcobalt-stimulated chromaffin granule carboxypeptidaseenkephalin convertaseinsulin granule-associated carboxypeptidaseprohormone-processing carboxypeptidase | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q7Z7L1 | P16870 | |
| Ensembl transtripts involved in fusion gene | ENST00000308377, ENST00000394566, | ENST00000402744, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 5 X 5=150 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLFN11 [Title/Abstract] AND CPE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLFN11 | GO:0006974 | cellular response to DNA damage stimulus | 29395061 |
| Hgene | SLFN11 | GO:0008156 | negative regulation of DNA replication | 29395061 |
| Hgene | SLFN11 | GO:0010942 | positive regulation of cell death | 29395061 |
| Hgene | SLFN11 | GO:0043111 | replication fork arrest | 29395061 |
| Tgene | CPE | GO:0016055 | Wnt signaling pathway | 22824791 |
| Tgene | CPE | GO:0072657 | protein localization to membrane | 19166515 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF935865 | SLFN11 | chr17 | 33680029 | - | CPE | chr4 | 166385720 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000308377 | ENST00000402744 | SLFN11 | chr17 | 33680029 | - | CPE | chr4 | 166385720 | + |
| intron-3CDS | ENST00000394566 | ENST00000402744 | SLFN11 | chr17 | 33680029 | - | CPE | chr4 | 166385720 | + |
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FusionProtFeatures for SLFN11_CPE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLFN11 | CPE |