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Fusion gene ID: 34667 |
FusionGeneSummary for SLCO4A1_GCDH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLCO4A1_GCDH | Fusion gene ID: 34667 | Hgene | Tgene | Gene symbol | SLCO4A1 | GCDH | Gene ID | 28231 | 2639 |
| Gene name | solute carrier organic anion transporter family member 4A1 | glutaryl-CoA dehydrogenase | |
| Synonyms | OATP-E|OATP1|OATP4A1|OATPE|OATPRP1|POAT|SLC21A12 | ACAD5|GCD | |
| Cytomap | 20q13.33 | 19p13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | solute carrier organic anion transporter family member 4A1OATP-RP1colon organic anion transporterorganic anion transporter polypeptide-related protein 1organic anion transporting polypeptide Esodium-independent organic anion transporter Esolute carr | glutaryl-CoA dehydrogenase, mitochondrialglutaryl-Coenzyme A dehydrogenasetruncated GCDHtruncated glutaryl-CoA dehydrogenase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96BD0 | Q92947 | |
| Ensembl transtripts involved in fusion gene | ENST00000217159, ENST00000370507, ENST00000470412, | ENST00000222214, ENST00000591470, ENST00000457854, ENST00000422947, ENST00000588242, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 6 X 7 X 4=168 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/50*10)=0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLCO4A1 [Title/Abstract] AND GCDH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GCDH | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 25416781 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF761104 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000217159 | ENST00000222214 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| Frame-shift | ENST00000217159 | ENST00000591470 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| Frame-shift | ENST00000217159 | ENST00000457854 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| Frame-shift | ENST00000217159 | ENST00000422947 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| 5CDS-intron | ENST00000217159 | ENST00000588242 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| Frame-shift | ENST00000370507 | ENST00000222214 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| Frame-shift | ENST00000370507 | ENST00000591470 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| Frame-shift | ENST00000370507 | ENST00000457854 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| Frame-shift | ENST00000370507 | ENST00000422947 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| 5CDS-intron | ENST00000370507 | ENST00000588242 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| 3UTR-3CDS | ENST00000470412 | ENST00000222214 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| 3UTR-3CDS | ENST00000470412 | ENST00000591470 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| 3UTR-3CDS | ENST00000470412 | ENST00000457854 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| 3UTR-3CDS | ENST00000470412 | ENST00000422947 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
| 3UTR-intron | ENST00000470412 | ENST00000588242 | SLCO4A1 | chr20 | 61300394 | - | GCDH | chr19 | 13006899 | - |
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FusionProtFeatures for SLCO4A1_GCDH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLCO4A1 | GCDH |