|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 34622 |
FusionGeneSummary for SLC7A6_PLA2G15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC7A6_PLA2G15 | Fusion gene ID: 34622 | Hgene | Tgene | Gene symbol | SLC7A6 | PLA2G15 | Gene ID | 9057 | 23659 |
| Gene name | solute carrier family 7 member 6 | phospholipase A2 group XV | |
| Synonyms | LAT-2|LAT3|y+LAT-2 | ACS|GXVPLA2|LLPL|LPLA2|LYPLA3 | |
| Cytomap | 16q22.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Y+L amino acid transporter 2amino acid permeasecationic amino acid transporter, y+ systemsolute carrier family 7 (amino acid transporter light chain, y+L system), member 6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6y | group XV phospholipase A21-O-acylceramide synthaseLCAT-like lysophospholipaselysophospholipase 3 (lysosomal phospholipase A2)lysosomal phospholipase A2 | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q92536 | Q8NCC3 | |
| Ensembl transtripts involved in fusion gene | ENST00000219343, ENST00000566454, | ENST00000413021, ENST00000219345, ENST00000566188, ENST00000444212, ENST00000568599, | |
| Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SLC7A6 [Title/Abstract] AND PLA2G15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PLA2G15 | GO:0006650 | glycerophospholipid metabolic process | 20410020 |
| Tgene | PLA2G15 | GO:0006672 | ceramide metabolic process | 20410020 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-BK-A139-02A | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000219343 | ENST00000413021 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-3CDS | ENST00000219343 | ENST00000219345 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-3CDS | ENST00000219343 | ENST00000566188 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-intron | ENST00000219343 | ENST00000444212 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-intron | ENST00000219343 | ENST00000568599 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-3CDS | ENST00000566454 | ENST00000413021 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-3CDS | ENST00000566454 | ENST00000219345 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-3CDS | ENST00000566454 | ENST00000566188 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-intron | ENST00000566454 | ENST00000444212 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
| 5UTR-intron | ENST00000566454 | ENST00000568599 | SLC7A6 | chr16 | 68300624 | + | PLA2G15 | chr16 | 68288822 | + |
Top |
FusionProtFeatures for SLC7A6_PLA2G15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC7A6 | PLA2G15 |