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Fusion gene ID: 34575 |
FusionGeneSummary for SLC50A1_SLC1A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC50A1_SLC1A2 | Fusion gene ID: 34575 | Hgene | Tgene | Gene symbol | SLC50A1 | SLC1A2 | Gene ID | 55974 | 6506 |
| Gene name | solute carrier family 50 member 1 | solute carrier family 1 member 2 | |
| Synonyms | HsSWEET1|RAG1AP1|SCP|SWEET1|slv | EAAT2|EIEE41|GLT-1|HBGT | |
| Cytomap | 1q22 | 11p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sugar transporter SWEET1RAG1-activating protein 1RP11-540D14.5RZPDo834D038Dprobable sugar transporter RAG1AP1recombination activating gene 1 activating protein 1solute carrier family 50 (sugar efflux transporter), member 1solute carrier family 50 ( | excitatory amino acid transporter 2excitotoxic amino acid transporter 2glutamate/aspartate transporter IIsodium-dependent glutamate/aspartate transporter 2solute carrier family 1 (glial high affinity glutamate transporter), member 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9BRV3 | P43004 | |
| Ensembl transtripts involved in fusion gene | ENST00000484157, ENST00000303343, ENST00000368404, ENST00000368401, ENST00000368405, | ENST00000278379, ENST00000395750, ENST00000395753, ENST00000606205, ENST00000479543, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 9 X 8 X 5=360 |
| # samples | 2 | 11 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC50A1 [Title/Abstract] AND SLC1A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SLC1A2 | GO:0015813 | L-glutamate transmembrane transport | 26690923 |
| Tgene | SLC1A2 | GO:0070207 | protein homotrimerization | 15265858|15483603 |
| Tgene | SLC1A2 | GO:0070779 | D-aspartate import across plasma membrane | 7521911 |
| Tgene | SLC1A2 | GO:0098712 | L-glutamate import across plasma membrane | 7521911|15265858|26690923 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA269573 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000484157 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| intron-3UTR | ENST00000484157 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| intron-3UTR | ENST00000484157 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| intron-intron | ENST00000484157 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| intron-intron | ENST00000484157 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-3UTR | ENST00000303343 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-3UTR | ENST00000303343 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-3UTR | ENST00000303343 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-intron | ENST00000303343 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-intron | ENST00000303343 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-3UTR | ENST00000368404 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-3UTR | ENST00000368404 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-3UTR | ENST00000368404 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-intron | ENST00000368404 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5CDS-intron | ENST00000368404 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5UTR-3UTR | ENST00000368401 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5UTR-3UTR | ENST00000368401 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5UTR-3UTR | ENST00000368401 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5UTR-intron | ENST00000368401 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 5UTR-intron | ENST00000368401 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 3UTR-3UTR | ENST00000368405 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 3UTR-3UTR | ENST00000368405 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 3UTR-3UTR | ENST00000368405 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 3UTR-intron | ENST00000368405 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
| 3UTR-intron | ENST00000368405 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
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FusionProtFeatures for SLC50A1_SLC1A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC50A1 | SLC1A2 |