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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 34565

FusionGeneSummary for SLC4A4_SLC4A4

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC4A4_SLC4A4
Fusion gene ID: 34565
HgeneTgene
Gene symbol

SLC4A4

SLC4A4

Gene ID

8671

8671

Gene namesolute carrier family 4 member 4solute carrier family 4 member 4
SynonymsHNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBCHNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBC
Cytomap

4q13.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionelectrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransporterelectrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransporter
Modification date2018052320180523
UniProtAcc

Q9Y6R1

Q9Y6R1

Ensembl transtripts involved in fusion geneENST00000264485, ENST00000425175, 
ENST00000351898, ENST00000340595, 
ENST00000514331, ENST00000512686, 
ENST00000264485, ENST00000425175, 
ENST00000351898, ENST00000340595, 
ENST00000514331, ENST00000512686, 
Fusion gene scores* DoF score7 X 7 X 4=19610 X 8 X 5=400
# samples 911
** MAII scorelog2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC4A4 [Title/Abstract] AND SLC4A4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC4A4

GO:0006814

sodium ion transport

16769890

TgeneSLC4A4

GO:0006814

sodium ion transport

16769890


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF924222SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
ChiTaRS3.1W39298SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264485ENST00000264485SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000264485ENST00000425175SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000264485ENST00000351898SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000264485ENST00000340595SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000264485ENST00000514331SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000264485ENST00000512686SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000425175ENST00000264485SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000425175ENST00000425175SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000425175ENST00000351898SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000425175ENST00000340595SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000425175ENST00000514331SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000425175ENST00000512686SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000351898ENST00000264485SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000351898ENST00000425175SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000351898ENST00000351898SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000351898ENST00000340595SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000351898ENST00000514331SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000351898ENST00000512686SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000340595ENST00000264485SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000340595ENST00000425175SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000340595ENST00000351898SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000340595ENST00000340595SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000340595ENST00000514331SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000340595ENST00000512686SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
3UTR-3CDSENST00000514331ENST00000264485SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
3UTR-3CDSENST00000514331ENST00000425175SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
3UTR-3CDSENST00000514331ENST00000351898SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
3UTR-3CDSENST00000514331ENST00000340595SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
3UTR-3UTRENST00000514331ENST00000514331SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
3UTR-3UTRENST00000514331ENST00000512686SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000512686ENST00000264485SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000512686ENST00000425175SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000512686ENST00000351898SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
Frame-shiftENST00000512686ENST00000340595SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000512686ENST00000514331SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
5CDS-3UTRENST00000512686ENST00000512686SLC4A4chr4

72332218

+SLC4A4chr4

72306404

+
In-frameENST00000264485ENST00000264485SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
In-frameENST00000264485ENST00000425175SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000264485ENST00000351898SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000264485ENST00000340595SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000264485ENST00000514331SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000264485ENST00000512686SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
In-frameENST00000425175ENST00000264485SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
In-frameENST00000425175ENST00000425175SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000425175ENST00000351898SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000425175ENST00000340595SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000425175ENST00000514331SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000425175ENST00000512686SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-3CDSENST00000351898ENST00000264485SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-3CDSENST00000351898ENST00000425175SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000351898ENST00000351898SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000351898ENST00000340595SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000351898ENST00000514331SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000351898ENST00000512686SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
In-frameENST00000340595ENST00000264485SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
In-frameENST00000340595ENST00000425175SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000340595ENST00000351898SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000340595ENST00000340595SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000340595ENST00000514331SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
5CDS-intronENST00000340595ENST00000512686SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-3CDSENST00000514331ENST00000264485SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-3CDSENST00000514331ENST00000425175SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000514331ENST00000351898SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000514331ENST00000340595SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000514331ENST00000514331SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000514331ENST00000512686SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-3CDSENST00000512686ENST00000264485SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-3CDSENST00000512686ENST00000425175SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000512686ENST00000351898SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000512686ENST00000340595SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000512686ENST00000514331SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+
intron-intronENST00000512686ENST00000512686SLC4A4chr4

72412121

-SLC4A4chr4

72413363

+

Top

FusionProtFeatures for SLC4A4_SLC4A4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC4A4

Q9Y6R1

SLC4A4

Q9Y6R1