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Fusion gene ID: 34563

FusionGeneSummary for SLC4A4_GOLGA4

Fusion gene summary

Fusion gene information	Fusion gene name: SLC4A4_GOLGA4
	Fusion gene ID: 34563
		Hgene	Tgene
	Gene symbol	SLC4A4	GOLGA4
	Gene ID	8671	2803
	Gene name	solute carrier family 4 member 4	golgin A4
	Synonyms	HNBC1\|KNBC\|NBC1\|NBC2\|NBCe1-A\|SLC4A5\|hhNMC\|kNBC1\|pNBC	CRPF46\|GCP2\|GOLG\|MU-RMS-40.18\|p230
	Cytomap	4q13.3	3p22.2
	Type of gene	protein-coding	protein-coding
	Description	electrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransporter	golgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230
	Modification date	20180523	20180519
	UniProtAcc	Q9Y6R1	Q13439
	Ensembl transtripts involved in fusion gene	ENST00000264485, ENST00000425175, ENST00000351898, ENST00000340595, ENST00000514331, ENST00000512686,	ENST00000361924, ENST00000435830, ENST00000444882, ENST00000356847,
Fusion gene scores	* DoF score	7 X 7 X 4=196	5 X 5 X 3=75
	# samples	9	5
	** MAII score	log2(9/196*10)=-1.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC4A4 [Title/Abstract] AND GOLGA4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC4A4	GO:0006814	sodium ion transport	16769890
Tgene	GOLGA4	GO:0043001	Golgi to plasma membrane protein transport	15265687
Tgene	GOLGA4	GO:0045773	positive regulation of axon extension	22705394

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-VP-A875-01A	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000264485	ENST00000361924	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000264485	ENST00000435830	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000264485	ENST00000444882	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000264485	ENST00000356847	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
In-frame	ENST00000425175	ENST00000361924	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000425175	ENST00000435830	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000425175	ENST00000444882	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000425175	ENST00000356847	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-3CDS	ENST00000351898	ENST00000361924	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000351898	ENST00000435830	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000351898	ENST00000444882	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000351898	ENST00000356847	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
In-frame	ENST00000340595	ENST00000361924	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000340595	ENST00000435830	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000340595	ENST00000444882	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
5CDS-intron	ENST00000340595	ENST00000356847	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-3CDS	ENST00000514331	ENST00000361924	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000514331	ENST00000435830	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000514331	ENST00000444882	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000514331	ENST00000356847	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-3CDS	ENST00000512686	ENST00000361924	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000512686	ENST00000435830	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000512686	ENST00000444882	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+
intron-intron	ENST00000512686	ENST00000356847	SLC4A4	chr4	72413437	+	GOLGA4	chr3	37396592	+

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FusionProtFeatures for SLC4A4_GOLGA4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SLC4A4 Q9Y6R1	GOLGA4 Q13439

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Fusion gene ID: 34563

FusionGeneSummary for SLC4A4_GOLGA4

FusionProtFeatures for SLC4A4_GOLGA4