|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 34560 |
FusionGeneSummary for SLC4A4_ARHGAP6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC4A4_ARHGAP6 | Fusion gene ID: 34560 | Hgene | Tgene | Gene symbol | SLC4A4 | ARHGAP6 | Gene ID | 8671 | 395 |
| Gene name | solute carrier family 4 member 4 | Rho GTPase activating protein 6 | |
| Synonyms | HNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBC | RHOGAP6|RHOGAPX-1 | |
| Cytomap | 4q13.3 | Xp22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | electrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransporter | rho GTPase-activating protein 6Rho-type GTPase-activating protein RhoGAPX-1rho-type GTPase-activating protein 6 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y6R1 | O43182 | |
| Ensembl transtripts involved in fusion gene | ENST00000264485, ENST00000425175, ENST00000351898, ENST00000340595, ENST00000514331, ENST00000512686, | ENST00000337414, ENST00000380718, ENST00000380732, ENST00000534860, ENST00000380736, ENST00000303025, ENST00000413512, ENST00000491514, | |
| Fusion gene scores | * DoF score | 7 X 7 X 4=196 | 6 X 3 X 6=108 |
| # samples | 9 | 7 | |
| ** MAII score | log2(9/196*10)=-1.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC4A4 [Title/Abstract] AND ARHGAP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC4A4 | GO:0006814 | sodium ion transport | 16769890 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-M7-A725-01A | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264485 | ENST00000337414 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000264485 | ENST00000380718 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000264485 | ENST00000380732 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000264485 | ENST00000534860 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000264485 | ENST00000380736 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000264485 | ENST00000303025 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000264485 | ENST00000413512 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-intron | ENST00000264485 | ENST00000491514 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000425175 | ENST00000337414 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000425175 | ENST00000380718 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000425175 | ENST00000380732 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000425175 | ENST00000534860 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000425175 | ENST00000380736 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000425175 | ENST00000303025 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000425175 | ENST00000413512 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-intron | ENST00000425175 | ENST00000491514 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000351898 | ENST00000337414 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000351898 | ENST00000380718 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000351898 | ENST00000380732 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000351898 | ENST00000534860 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000351898 | ENST00000380736 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000351898 | ENST00000303025 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000351898 | ENST00000413512 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-intron | ENST00000351898 | ENST00000491514 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000340595 | ENST00000337414 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000340595 | ENST00000380718 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000340595 | ENST00000380732 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000340595 | ENST00000534860 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000340595 | ENST00000380736 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000340595 | ENST00000303025 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000340595 | ENST00000413512 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-intron | ENST00000340595 | ENST00000491514 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 3UTR-3CDS | ENST00000514331 | ENST00000337414 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 3UTR-3CDS | ENST00000514331 | ENST00000380718 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 3UTR-3CDS | ENST00000514331 | ENST00000380732 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 3UTR-3CDS | ENST00000514331 | ENST00000534860 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 3UTR-5UTR | ENST00000514331 | ENST00000380736 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 3UTR-5UTR | ENST00000514331 | ENST00000303025 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 3UTR-5UTR | ENST00000514331 | ENST00000413512 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 3UTR-intron | ENST00000514331 | ENST00000491514 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000512686 | ENST00000337414 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000512686 | ENST00000380718 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000512686 | ENST00000380732 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| In-frame | ENST00000512686 | ENST00000534860 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000512686 | ENST00000380736 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000512686 | ENST00000303025 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-5UTR | ENST00000512686 | ENST00000413512 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
| 5CDS-intron | ENST00000512686 | ENST00000491514 | SLC4A4 | chr4 | 72263370 | + | ARHGAP6 | chrX | 11272827 | - |
Top |
FusionProtFeatures for SLC4A4_ARHGAP6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC4A4 | ARHGAP6 |