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Fusion gene ID: 34506 |
FusionGeneSummary for SLC44A1_PALM2-AKAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC44A1_PALM2-AKAP2 | Fusion gene ID: 34506 | Hgene | Tgene | Gene symbol | SLC44A1 | PALM2-AKAP2 | Gene ID | 23446 | 445815 |
| Gene name | solute carrier family 44 member 1 | PALM2-AKAP2 readthrough | |
| Synonyms | CD92|CDW92|CHTL1|CTL1 | AKAP2 | |
| Cytomap | 9q31.1-q31.2 | 9q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | choline transporter-like protein 1CDW92 antigensolute carrier family 44 (choline transporter), member 1 | PALM2-AKAP2 proteinPALM2-AKAP2 readthrough transcript | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8WWI5 | ||
| Ensembl transtripts involved in fusion gene | ENST00000374723, ENST00000374720, ENST00000374724, ENST00000343170, ENST00000607692, | ENST00000374530, ENST00000302798, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 5 X 4 X 4=80 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC44A1 [Title/Abstract] AND PALM2-AKAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-SI-A71Q-01A | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000374723 | ENST00000374530 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| In-frame | ENST00000374723 | ENST00000302798 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| In-frame | ENST00000374720 | ENST00000374530 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| In-frame | ENST00000374720 | ENST00000302798 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| In-frame | ENST00000374724 | ENST00000374530 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| In-frame | ENST00000374724 | ENST00000302798 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| intron-3CDS | ENST00000343170 | ENST00000374530 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| intron-3CDS | ENST00000343170 | ENST00000302798 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| intron-3CDS | ENST00000607692 | ENST00000374530 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
| intron-3CDS | ENST00000607692 | ENST00000302798 | SLC44A1 | chr9 | 108007185 | + | PALM2-AKAP2 | chr9 | 112898407 | + |
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FusionProtFeatures for SLC44A1_PALM2-AKAP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC44A1 | PALM2-AKAP2 |