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Fusion gene ID: 34480

FusionGeneSummary for SLC3A2_GRAP2

Fusion gene summary

Fusion gene information	Fusion gene name: SLC3A2_GRAP2
	Fusion gene ID: 34480
		Hgene	Tgene
	Gene symbol	SLC3A2	GRAP2
	Gene ID	6520	9402
	Gene name	solute carrier family 3 member 2	GRB2 related adaptor protein 2
	Synonyms	4F2\|4F2HC\|4T2HC\|CD98\|CD98HC\|MDU1\|NACAE	GADS\|GRAP-2\|GRB2L\|GRBLG\|GRID\|GRPL\|GrbX\|Grf40\|Mona\|P38
	Cytomap	11q12.3	22q13.1
	Type of gene	protein-coding	protein-coding
	Description	4F2 cell-surface antigen heavy chainCD98 heavy chainantigen defined by monoclonal antibody 4F2, heavy chainantigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43lymphocyte activation antigen 4F2 large subunitmonoclonal antibody 44D7	GRB2-related adapter protein 2GRB-2-like proteinGRB2-related protein with insert domainSH3-SH2-SH3 adapter MonaSH3-SH2-SH3 adaptor moleculeadapter protein GRIDgrf-40grf40 adapter proteingrowth factor receptor-binding proteingrowth factor receptor
	Modification date	20180522	20180522
	UniProtAcc	P08195	O75791
	Ensembl transtripts involved in fusion gene	ENST00000377892, ENST00000377890, ENST00000377891, ENST00000377889, ENST00000535296, ENST00000338663, ENST00000538682, ENST00000536981,	ENST00000543252, ENST00000344138, ENST00000540310, ENST00000478445, ENST00000544756, ENST00000399090, ENST00000407075,
Fusion gene scores	* DoF score	8 X 7 X 6=336	6 X 4 X 5=120
	# samples	11	7
	** MAII score	log2(11/336*10)=-1.6109577092541 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC3A2 [Title/Abstract] AND GRAP2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SKCM	TCGA-FS-A1ZK-06A	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000377892	ENST00000543252	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377892	ENST00000344138	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377892	ENST00000540310	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377892	ENST00000478445	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377892	ENST00000544756	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377892	ENST00000399090	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377892	ENST00000407075	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377890	ENST00000543252	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377890	ENST00000344138	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377890	ENST00000540310	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377890	ENST00000478445	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377890	ENST00000544756	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377890	ENST00000399090	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377890	ENST00000407075	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377891	ENST00000543252	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377891	ENST00000344138	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377891	ENST00000540310	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377891	ENST00000478445	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377891	ENST00000544756	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377891	ENST00000399090	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377891	ENST00000407075	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377889	ENST00000543252	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377889	ENST00000344138	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000377889	ENST00000540310	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377889	ENST00000478445	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377889	ENST00000544756	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377889	ENST00000399090	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000377889	ENST00000407075	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000535296	ENST00000543252	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000535296	ENST00000344138	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000535296	ENST00000540310	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000535296	ENST00000478445	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000535296	ENST00000544756	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000535296	ENST00000399090	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000535296	ENST00000407075	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000338663	ENST00000543252	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000338663	ENST00000344138	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000338663	ENST00000540310	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000338663	ENST00000478445	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000338663	ENST00000544756	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000338663	ENST00000399090	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000338663	ENST00000407075	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
3UTR-3CDS	ENST00000538682	ENST00000543252	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
3UTR-3CDS	ENST00000538682	ENST00000344138	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
3UTR-3CDS	ENST00000538682	ENST00000540310	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
3UTR-intron	ENST00000538682	ENST00000478445	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
3UTR-intron	ENST00000538682	ENST00000544756	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
3UTR-intron	ENST00000538682	ENST00000399090	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
3UTR-intron	ENST00000538682	ENST00000407075	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000536981	ENST00000543252	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000536981	ENST00000344138	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
In-frame	ENST00000536981	ENST00000540310	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000536981	ENST00000478445	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000536981	ENST00000544756	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000536981	ENST00000399090	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+
5CDS-intron	ENST00000536981	ENST00000407075	SLC3A2	chr11	62653080	+	GRAP2	chr22	40365415	+

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FusionProtFeatures for SLC3A2_GRAP2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SLC3A2 P08195	GRAP2 O75791

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Fusion gene ID: 34480

FusionGeneSummary for SLC3A2_GRAP2

FusionProtFeatures for SLC3A2_GRAP2