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Fusion gene ID: 34472

FusionGeneSummary for SLC39A9_RAD51B

Fusion gene summary

Fusion gene information	Fusion gene name: SLC39A9_RAD51B
	Fusion gene ID: 34472
		Hgene	Tgene
	Gene symbol	SLC39A9	RAD51B
	Gene ID	55334	5890
	Gene name	solute carrier family 39 member 9	RAD51 paralog B
	Synonyms	ZIP-9\|ZIP9	R51H2\|RAD51L1\|REC2
	Cytomap	14q24.1	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	zinc transporter ZIP9solute carrier family 39 (zinc transporter), member 9zinc transporter SLC39A9zrt- and Irt-like protein 9	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
	Modification date	20180519	20180523
	UniProtAcc	Q9NUM3	O15315
	Ensembl transtripts involved in fusion gene	ENST00000555245, ENST00000556605, ENST00000336643, ENST00000031146, ENST00000557046,	ENST00000487861, ENST00000471583, ENST00000487270, ENST00000488612, ENST00000390683, ENST00000469165,
Fusion gene scores	* DoF score	6 X 4 X 4=96	25 X 15 X 8=3000
	# samples	7	33
	** MAII score	log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(33/3000*10)=-3.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC39A9 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-D8-A1XQ-01A	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000555245	ENST00000487861	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
intron-intron	ENST00000555245	ENST00000471583	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
intron-intron	ENST00000555245	ENST00000487270	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
intron-intron	ENST00000555245	ENST00000488612	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
intron-intron	ENST00000555245	ENST00000390683	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
intron-intron	ENST00000555245	ENST00000469165	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000556605	ENST00000487861	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000556605	ENST00000471583	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000556605	ENST00000487270	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000556605	ENST00000488612	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000556605	ENST00000390683	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000556605	ENST00000469165	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000336643	ENST00000487861	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000336643	ENST00000471583	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000336643	ENST00000487270	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000336643	ENST00000488612	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000336643	ENST00000390683	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000336643	ENST00000469165	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000031146	ENST00000487861	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000031146	ENST00000471583	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000031146	ENST00000487270	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000031146	ENST00000488612	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000031146	ENST00000390683	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000031146	ENST00000469165	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000557046	ENST00000487861	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000557046	ENST00000471583	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000557046	ENST00000487270	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000557046	ENST00000488612	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000557046	ENST00000390683	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+
5CDS-intron	ENST00000557046	ENST00000469165	SLC39A9	chr14	69866182	+	RAD51B	chr14	69149654	+

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FusionProtFeatures for SLC39A9_RAD51B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SLC39A9 Q9NUM3	RAD51B O15315

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Fusion gene ID: 34472

FusionGeneSummary for SLC39A9_RAD51B

FusionProtFeatures for SLC39A9_RAD51B