|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 34337 |
FusionGeneSummary for SLC34A2_CLDN7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC34A2_CLDN7 | Fusion gene ID: 34337 | Hgene | Tgene | Gene symbol | SLC34A2 | CLDN7 | Gene ID | 10568 | 1366 |
| Gene name | solute carrier family 34 member 2 | claudin 7 | |
| Synonyms | NAPI-3B|NAPI-IIb|NPTIIb | CEPTRL2|CLDN-7|CPETRL2|Hs.84359|claudin-1 | |
| Cytomap | 4p15.2 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transpor | claudin-7clostridium perfringens enterotoxin receptor-like 2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O95436 | O95471 | |
| Ensembl transtripts involved in fusion gene | ENST00000504570, ENST00000382051, ENST00000503434, ENST00000510033, | ENST00000360325, ENST00000538261, ENST00000397317, ENST00000571881, ENST00000573745, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 5 X 1 X 4=20 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/90*10)=0.289506617194985 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/20*10)=1.58496250072116 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SLC34A2 [Title/Abstract] AND CLDN7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC34A2 | GO:0006817 | phosphate ion transport | 10329428|10610722|12488042 |
| Hgene | SLC34A2 | GO:0030643 | cellular phosphate ion homeostasis | 10610722 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | THCA | TCGA-FE-A231-01A | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| TCGA | RV | THCA | TCGA-IM-A3U3-01A | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000504570 | ENST00000360325 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000504570 | ENST00000538261 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000504570 | ENST00000397317 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000504570 | ENST00000571881 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-5UTR | ENST00000504570 | ENST00000573745 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| 5CDS-intron | ENST00000382051 | ENST00000360325 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| 5CDS-intron | ENST00000382051 | ENST00000538261 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| 5CDS-intron | ENST00000382051 | ENST00000397317 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| 5CDS-intron | ENST00000382051 | ENST00000571881 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| 5CDS-5UTR | ENST00000382051 | ENST00000573745 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000503434 | ENST00000360325 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000503434 | ENST00000538261 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000503434 | ENST00000397317 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000503434 | ENST00000571881 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-5UTR | ENST00000503434 | ENST00000573745 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000510033 | ENST00000360325 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000510033 | ENST00000538261 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000510033 | ENST00000397317 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-intron | ENST00000510033 | ENST00000571881 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
| intron-5UTR | ENST00000510033 | ENST00000573745 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
Top |
FusionProtFeatures for SLC34A2_CLDN7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC34A2 | CLDN7 |