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Fusion gene ID: 34294 |
FusionGeneSummary for SLC2A12_SGK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC2A12_SGK1 | Fusion gene ID: 34294 | Hgene | Tgene | Gene symbol | SLC2A12 | SGK1 | Gene ID | 154091 | 6446 |
| Gene name | solute carrier family 2 member 12 | serum/glucocorticoid regulated kinase 1 | |
| Synonyms | GLUT12|GLUT8 | SGK | |
| Cytomap | 6q23.2 | 6q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | solute carrier family 2, facilitated glucose transporter member 12GLUT-12glucose transporter type 12solute carrier family 2 (facilitated glucose transporter), member 12 | serine/threonine-protein kinase Sgk1Sgk1 variant i3serine/threonine protein kinase SGK | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TD20 | O00141 | |
| Ensembl transtripts involved in fusion gene | ENST00000275230, | ENST00000367858, ENST00000524929, ENST00000413996, ENST00000237305, ENST00000367857, ENST00000528577, ENST00000475719, ENST00000489458, | |
| Fusion gene scores | * DoF score | 3 X 3 X 4=36 | 7 X 7 X 5=245 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/245*10)=-1.4447848426729 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC2A12 [Title/Abstract] AND SGK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-BA-4078-01A | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| TCGA | RV | UCEC | TCGA-BK-A139-01A | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000275230 | ENST00000367858 | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| Frame-shift | ENST00000275230 | ENST00000524929 | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000413996 | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000237305 | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000367857 | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000528577 | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000475719 | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000489458 | SLC2A12 | chr6 | 134373516 | - | SGK1 | chr6 | 134583286 | - |
| Frame-shift | ENST00000275230 | ENST00000367858 | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
| In-frame | ENST00000275230 | ENST00000524929 | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000413996 | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000237305 | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000367857 | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000528577 | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000475719 | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
| 5CDS-intron | ENST00000275230 | ENST00000489458 | SLC2A12 | chr6 | 134349519 | - | SGK1 | chr6 | 134583286 | - |
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FusionProtFeatures for SLC2A12_SGK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC2A12 | SGK1 |