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Center for Computational Systems Medicine
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FusionGeneSummary

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Fusion gene ID: 34202

FusionGeneSummary for SLC25A21_MIPOL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A21_MIPOL1
Fusion gene ID: 34202
HgeneTgene
Gene symbol

SLC25A21

MIPOL1

Gene ID

89874

145282

Gene namesolute carrier family 25 member 21mirror-image polydactyly 1
SynonymsODC|ODC1CCDC193
Cytomap

14q13.3

14q13.3-q21.1

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial 2-oxodicarboxylate carrieroxodicarboxylate carriersolute carrier family 25 (mitochondrial oxoadipate carrier), member 21solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21mirror-image polydactyly gene 1 protein
Modification date2018052320180519
UniProtAcc

Q9BQT8

Q8TD10

Ensembl transtripts involved in fusion geneENST00000555449, ENST00000331299, 
ENST00000557611, 		ENST00000536774, 
ENST00000327441, ENST00000539062, 
ENST00000556451, ENST00000396294, 
ENST00000545536, ENST00000537471, 
ENST00000539174, 
Fusion gene scores* DoF score2 X 3 X 3=189 X 7 X 7=441
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A21 [Title/Abstract] AND MIPOL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-C4-A0F7-01ASLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
TCGARVLUADTCGA-78-7161-01ASLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000555449ENST00000536774SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000555449ENST00000327441SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000555449ENST00000539062SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-5UTRENST00000555449ENST00000556451SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000555449ENST00000396294SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000555449ENST00000545536SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000555449ENST00000537471SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000555449ENST00000539174SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000331299ENST00000536774SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000331299ENST00000327441SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000331299ENST00000539062SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-5UTRENST00000331299ENST00000556451SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000331299ENST00000396294SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000331299ENST00000545536SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000331299ENST00000537471SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5CDS-intronENST00000331299ENST00000539174SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5UTR-intronENST00000557611ENST00000536774SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5UTR-intronENST00000557611ENST00000327441SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5UTR-intronENST00000557611ENST00000539062SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5UTR-5UTRENST00000557611ENST00000556451SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5UTR-intronENST00000557611ENST00000396294SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5UTR-intronENST00000557611ENST00000545536SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5UTR-intronENST00000557611ENST00000537471SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
5UTR-intronENST00000557611ENST00000539174SLC25A21chr14

37641486

-MIPOL1chr14

37681435

+
In-frameENST00000555449ENST00000536774SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000555449ENST00000327441SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000555449ENST00000539062SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000555449ENST00000556451SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000555449ENST00000396294SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000555449ENST00000545536SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000555449ENST00000537471SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
5CDS-intronENST00000555449ENST00000539174SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000331299ENST00000536774SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000331299ENST00000327441SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000331299ENST00000539062SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000331299ENST00000556451SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000331299ENST00000396294SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000331299ENST00000545536SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
In-frameENST00000331299ENST00000537471SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
5CDS-intronENST00000331299ENST00000539174SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
intron-3CDSENST00000557611ENST00000536774SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
intron-3CDSENST00000557611ENST00000327441SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
intron-3CDSENST00000557611ENST00000539062SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
intron-3CDSENST00000557611ENST00000556451SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
intron-3CDSENST00000557611ENST00000396294SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
intron-3CDSENST00000557611ENST00000545536SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
intron-3CDSENST00000557611ENST00000537471SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+
intron-intronENST00000557611ENST00000539174SLC25A21chr14

37194775

-MIPOL1chr14

37892060

+

Top

FusionProtFeatures for SLC25A21_MIPOL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A21

Q9BQT8

MIPOL1

Q8TD10