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Fusion gene ID: 34178 |
FusionGeneSummary for SLC25A13_CD2AP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC25A13_CD2AP | Fusion gene ID: 34178 | Hgene | Tgene | Gene symbol | SLC25A13 | CD2AP | Gene ID | 10165 | 23607 |
| Gene name | solute carrier family 25 member 13 | CD2 associated protein | |
| Synonyms | ARALAR2|CITRIN|CTLN2 | CMS | |
| Cytomap | 7q21.3 | 6p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium-binding mitochondrial carrier protein Aralar2mitochondrial aspartate glutamate carrier 2solute carrier family 25 (aspartate/glutamate carrier), member 13 | CD2-associated proteinCas ligand with multiple Src homology 3 (SH3) domainsadapter protein CMScas ligand with multiple SH3 domains | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9UJS0 | Q9Y5K6 | |
| Ensembl transtripts involved in fusion gene | ENST00000265631, ENST00000416240, ENST00000542654, ENST00000494085, | ENST00000359314, ENST00000486693, | |
| Fusion gene scores | * DoF score | 9 X 7 X 8=504 | 7 X 7 X 5=245 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/504*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC25A13 [Title/Abstract] AND CD2AP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC25A13 | GO:0006754 | ATP biosynthetic process | 12851387 |
| Hgene | SLC25A13 | GO:0015810 | aspartate transmembrane transport | 11566871 |
| Hgene | SLC25A13 | GO:0015813 | L-glutamate transmembrane transport | 11566871 |
| Hgene | SLC25A13 | GO:0043490 | malate-aspartate shuttle | 11566871 |
| Hgene | SLC25A13 | GO:0045333 | cellular respiration | 12851387 |
| Hgene | SLC25A13 | GO:0051592 | response to calcium ion | 11566871 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | READ | TCGA-EI-6510-01A | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265631 | ENST00000359314 | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
| 5CDS-intron | ENST00000265631 | ENST00000486693 | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
| In-frame | ENST00000416240 | ENST00000359314 | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
| 5CDS-intron | ENST00000416240 | ENST00000486693 | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
| Frame-shift | ENST00000542654 | ENST00000359314 | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
| 5CDS-intron | ENST00000542654 | ENST00000486693 | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
| intron-3CDS | ENST00000494085 | ENST00000359314 | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
| intron-intron | ENST00000494085 | ENST00000486693 | SLC25A13 | chr7 | 95813589 | - | CD2AP | chr6 | 47512342 | + |
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FusionProtFeatures for SLC25A13_CD2AP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC25A13 | CD2AP |