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Fusion gene ID: 34160 |
FusionGeneSummary for SLC23A2_NDUFS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC23A2_NDUFS2 | Fusion gene ID: 34160 | Hgene | Tgene | Gene symbol | SLC23A2 | NDUFS2 | Gene ID | 9963 | 4720 |
| Gene name | solute carrier family 23 member 1 | NADH:ubiquinone oxidoreductase core subunit S2 | |
| Synonyms | SLC23A2|SVCT1|YSPL3 | CI-49 | |
| Cytomap | 5q31.2 | 1q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | solute carrier family 23 member 1Na(+)/L-ascorbic acid transporter 1hSVCT1sodium-dependent vitamin C transporter-1solute carrier family 23 (ascorbic acid transporter), member 1solute carrier family 23 (nucleobase transporters), member 1solute carrie | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialCI-49kDNADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)NADH-ubiquinone oxidoreductase 49 kDa subunitNADH-ubiquinone oxidoreductase NDUFS2 subunitcomp | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9UGH3 | O75306 | |
| Ensembl transtripts involved in fusion gene | ENST00000338244, ENST00000379333, ENST00000424750, ENST00000468355, | ENST00000367993, ENST00000392179, ENST00000476409, ENST00000465923, | |
| Fusion gene scores | * DoF score | 7 X 7 X 6=294 | 5 X 5 X 3=75 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/294*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC23A2 [Title/Abstract] AND NDUFS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC23A2 | GO:0006814 | sodium ion transport | 18094143 |
| Hgene | SLC23A2 | GO:0009636 | response to toxic substance | 17575980 |
| Hgene | SLC23A2 | GO:0015882 | L-ascorbic acid transmembrane transport | 10631088|11895172|18247577|18417304|19216494 |
| Hgene | SLC23A2 | GO:0070904 | transepithelial L-ascorbic acid transport | 18417304 |
| Tgene | NDUFS2 | GO:0006979 | response to oxidative stress | 12857734 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM708210 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000338244 | ENST00000367993 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000338244 | ENST00000392179 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-intron | ENST00000338244 | ENST00000476409 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000338244 | ENST00000465923 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000379333 | ENST00000367993 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000379333 | ENST00000392179 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-intron | ENST00000379333 | ENST00000476409 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000379333 | ENST00000465923 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000424750 | ENST00000367993 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000424750 | ENST00000392179 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-intron | ENST00000424750 | ENST00000476409 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000424750 | ENST00000465923 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000468355 | ENST00000367993 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000468355 | ENST00000392179 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-intron | ENST00000468355 | ENST00000476409 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
| intron-3UTR | ENST00000468355 | ENST00000465923 | SLC23A2 | chr20 | 4835006 | - | NDUFS2 | chr1 | 161184136 | + |
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FusionProtFeatures for SLC23A2_NDUFS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC23A2 | NDUFS2 |