|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 34015 |
FusionGeneSummary for SLC10A7_FKBP15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC10A7_FKBP15 | Fusion gene ID: 34015 | Hgene | Tgene | Gene symbol | SLC10A7 | FKBP15 | Gene ID | 84068 | 23307 |
| Gene name | solute carrier family 10 member 7 | FK506 binding protein 15 | |
| Synonyms | C4orf13|P7 | FKBP133|KIAA0674|PPP1R76 | |
| Cytomap | 4q31.22 | 9q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium/bile acid cotransporter 7Na(+)/bile acid cotransporter 7SBF-domain containing proteinsolute carrier family 10 (sodium/bile acid cotransporter family), member 7 | FK506-binding protein 15133 kDa FK506-binding protein133 kDa FKBPFK506 binding protein 15, 133kDaFK506-binding protein 133kDaFKBP-133FKBP-15WAFLWASP and FKBP-like proteinprotein phosphatase 1, regulatory subunit 76 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q0GE19 | Q5T1M5 | |
| Ensembl transtripts involved in fusion gene | ENST00000432059, ENST00000335472, ENST00000264986, ENST00000507030, ENST00000394062, ENST00000394059, ENST00000511315, ENST00000511374, ENST00000502607, | ENST00000238256, ENST00000493847, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 8 X 2=128 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/128*10)=-0.508146903670325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC10A7 [Title/Abstract] AND FKBP15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FKBP15 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-G9-6361-01A | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000432059 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000432059 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| In-frame | ENST00000335472 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 5CDS-intron | ENST00000335472 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 3UTR-3CDS | ENST00000264986 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 3UTR-intron | ENST00000264986 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| In-frame | ENST00000507030 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 5CDS-intron | ENST00000507030 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| In-frame | ENST00000394062 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 5CDS-intron | ENST00000394062 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-3CDS | ENST00000394059 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000394059 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-3CDS | ENST00000511315 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000511315 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-3CDS | ENST00000511374 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000511374 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-3CDS | ENST00000502607 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000502607 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
Top |
FusionProtFeatures for SLC10A7_FKBP15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC10A7 | FKBP15 |