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Fusion gene ID: 33986

FusionGeneSummary for SKIV2L_HCP5

Fusion gene summary

Fusion gene information	Fusion gene name: SKIV2L_HCP5
	Fusion gene ID: 33986
		Hgene	Tgene
	Gene symbol	SKIV2L	HCP5
	Gene ID	6499	10866
	Gene name	Ski2 like RNA helicase	HLA complex P5
	Synonyms	170A\|DDX13\|HLP\|SKI2\|SKI2W\|SKIV2\|SKIV2L1\|THES2	6S2650E\|D6S2650E\|P5-1
	Cytomap	6p21.33	6p21.33
	Type of gene	protein-coding	ncRNA
	Description	helicase SKI2WSKI2 homolog, superkiller viralicidic activity 2-likehelicase-like proteinsuperkiller viralicidic activity 2-like	HLA class I histocompatibility antigen protein P5HLA complex P5 (non-protein coding)HLA complex protein P5MHC class I region ORF
	Modification date	20180523	20180519
	UniProtAcc	Q15477
	Ensembl transtripts involved in fusion gene	ENST00000375394, ENST00000488648, ENST00000544581, ENST00000448219, ENST00000471547, ENST00000429465, ENST00000476338, ENST00000412823, ENST00000480914, ENST00000383336, ENST00000461360, ENST00000421789, ENST00000466463,	ENST00000414046, ENST00000419355, ENST00000457127, ENST00000423496,
Fusion gene scores	* DoF score	4 X 4 X 3=48	1 X 1 X 1=1
	# samples	4	1
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: SKIV2L [Title/Abstract] AND HCP5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	UCEC	TCGA-AJ-A3QS-01A	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000375394	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
5CDS-intron	ENST00000375394	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
5CDS-intron	ENST00000375394	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
5CDS-intron	ENST00000375394	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000488648	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000488648	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000488648	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000488648	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
5CDS-intron	ENST00000544581	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
5CDS-intron	ENST00000544581	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
5CDS-intron	ENST00000544581	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
5CDS-intron	ENST00000544581	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000448219	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000448219	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000448219	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000448219	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000471547	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000471547	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000471547	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000471547	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000429465	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000429465	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000429465	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000429465	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000476338	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000476338	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000476338	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000476338	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000412823	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000412823	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000412823	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000412823	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000480914	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000480914	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000480914	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000480914	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000383336	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000383336	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000383336	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000383336	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000461360	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000461360	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000461360	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000461360	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000421789	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000421789	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000421789	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000421789	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000466463	ENST00000414046	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000466463	ENST00000419355	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000466463	ENST00000457127	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+
intron-intron	ENST00000466463	ENST00000423496	SKIV2L	chr6	31935154	+	HCP5	chr6	31444804	+

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FusionProtFeatures for SKIV2L_HCP5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SKIV2L Q15477	HCP5

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Fusion gene ID: 33986

FusionGeneSummary for SKIV2L_HCP5

FusionProtFeatures for SKIV2L_HCP5