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Fusion gene ID: 33938 |
FusionGeneSummary for SKA1_NBAS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SKA1_NBAS | Fusion gene ID: 33938 | Hgene | Tgene | Gene symbol | SKA1 | NBAS | Gene ID | 220134 | 51594 |
| Gene name | spindle and kinetochore associated complex subunit 1 | neuroblastoma amplified sequence | |
| Synonyms | C18orf24 | ILFS2|NAG|SOPH | |
| Cytomap | 18q21.1 | 2p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | spindle and kinetochore-associated protein 1spindle and KT (kinetochore) associated 1 | neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q96BD8 | A2RRP1 | |
| Ensembl transtripts involved in fusion gene | ENST00000285116, ENST00000398452, ENST00000417656, ENST00000488454, | ENST00000441750, ENST00000281513, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 9 X 3=216 |
| # samples | 1 | 9 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SKA1 [Title/Abstract] AND NBAS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SKA1 | GO:0031110 | regulation of microtubule polymerization or depolymerization | 19289083 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE618276 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000285116 | ENST00000441750 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
| In-frame | ENST00000285116 | ENST00000281513 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
| In-frame | ENST00000398452 | ENST00000441750 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
| In-frame | ENST00000398452 | ENST00000281513 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
| In-frame | ENST00000417656 | ENST00000441750 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
| In-frame | ENST00000417656 | ENST00000281513 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
| 5UTR-3CDS | ENST00000488454 | ENST00000441750 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
| 5UTR-3CDS | ENST00000488454 | ENST00000281513 | SKA1 | chr18 | 47902288 | + | NBAS | chr2 | 15449372 | - |
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FusionProtFeatures for SKA1_NBAS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SKA1 | NBAS |