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Fusion gene ID: 33920 |
FusionGeneSummary for SIPA1_RHOD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIPA1_RHOD | Fusion gene ID: 33920 | Hgene | Tgene | Gene symbol | SIPA1 | RHOD | Gene ID | 6494 | 29984 |
| Gene name | signal-induced proliferation-associated 1 | ras homolog family member D | |
| Synonyms | SPA1 | ARHD|RHOHP1|RHOM|Rho | |
| Cytomap | 11q13.1 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | signal-induced proliferation-associated protein 1GTPase-activating protein Spa-1p130 SPA-1signal-induced proliferation-associated gene 1sipa-1 | rho-related GTP-binding protein RhoDRho-related protein HP1ras homolog Dras homolog gene family, member Aras homolog gene family, member D | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96FS4 | O00212 | |
| Ensembl transtripts involved in fusion gene | ENST00000534313, ENST00000527525, ENST00000394224, ENST00000394227, | ENST00000308831, ENST00000533360, ENST00000532559, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 9 X 4 X 8=288 |
| # samples | 3 | 13 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/288*10)=-1.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SIPA1 [Title/Abstract] AND RHOD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-C5-A1M8-01A | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000534313 | ENST00000308831 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| Frame-shift | ENST00000534313 | ENST00000533360 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| 5CDS-intron | ENST00000534313 | ENST00000532559 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| Frame-shift | ENST00000527525 | ENST00000308831 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| Frame-shift | ENST00000527525 | ENST00000533360 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| 5CDS-intron | ENST00000527525 | ENST00000532559 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| Frame-shift | ENST00000394224 | ENST00000308831 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| Frame-shift | ENST00000394224 | ENST00000533360 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| 5CDS-intron | ENST00000394224 | ENST00000532559 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| Frame-shift | ENST00000394227 | ENST00000308831 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| Frame-shift | ENST00000394227 | ENST00000533360 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
| 5CDS-intron | ENST00000394227 | ENST00000532559 | SIPA1 | chr11 | 65415129 | + | RHOD | chr11 | 66833367 | + |
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FusionProtFeatures for SIPA1_RHOD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIPA1 | RHOD |