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Fusion gene ID: 33889 |
FusionGeneSummary for SIN3B_C19orf57 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIN3B_C19orf57 | Fusion gene ID: 33889 | Hgene | Tgene | Gene symbol | SIN3B | C19orf57 | Gene ID | 23309 | 79173 |
| Gene name | SIN3 transcription regulator family member B | chromosome 19 open reading frame 57 | |
| Synonyms | - | - | |
| Cytomap | 19p13.11 | 19p13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | paired amphipathic helix protein Sin3bSIN3 homolog B, transcriptional regulatorSIN3 transcription regulator homolog Bhistone deacetylase complex subunit Sin3btranscriptional corepressor Sin3b | uncharacterized protein C19orf57pre-T/NK cell associated protein (3B3) | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O75182 | Q0VDD7 | |
| Ensembl transtripts involved in fusion gene | ENST00000248054, ENST00000596802, ENST00000379803, ENST00000595541, ENST00000594235, | ENST00000586783, ENST00000454313, ENST00000346736, ENST00000591586, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 7 X 6 X 4=168 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SIN3B [Title/Abstract] AND C19orf57 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-MJ-A68H-01A | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000248054 | ENST00000586783 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000248054 | ENST00000454313 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000248054 | ENST00000346736 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000248054 | ENST00000591586 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000596802 | ENST00000586783 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000596802 | ENST00000454313 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000596802 | ENST00000346736 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000596802 | ENST00000591586 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000379803 | ENST00000586783 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000379803 | ENST00000454313 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000379803 | ENST00000346736 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| In-frame | ENST00000379803 | ENST00000591586 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| intron-3CDS | ENST00000595541 | ENST00000586783 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| intron-3CDS | ENST00000595541 | ENST00000454313 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| intron-3CDS | ENST00000595541 | ENST00000346736 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| intron-3CDS | ENST00000595541 | ENST00000591586 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| intron-3CDS | ENST00000594235 | ENST00000586783 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| intron-3CDS | ENST00000594235 | ENST00000454313 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| intron-3CDS | ENST00000594235 | ENST00000346736 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
| intron-3CDS | ENST00000594235 | ENST00000591586 | SIN3B | chr19 | 16952779 | + | C19orf57 | chr19 | 13996868 | - |
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FusionProtFeatures for SIN3B_C19orf57 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIN3B | C19orf57 |