|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 33850 |
FusionGeneSummary for SIK2_PIR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIK2_PIR | Fusion gene ID: 33850 | Hgene | Tgene | Gene symbol | SIK2 | PIR | Gene ID | 23235 | 8544 |
| Gene name | salt inducible kinase 2 | pirin | |
| Synonyms | LOH11CR1I|QIK|SIK-2|SNF1LK2 | - | |
| Cytomap | 11q23.1 | Xp22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase SIK2SNF1-like kinase 2qin-induced kinasesalt-inducible protein kinase 2salt-inducible serine/threonine kinase 2serine/threonine-protein kinase SNF1-like kinase 2 | pirinpirin (iron-binding nuclear protein)probable quercetin 2,3-dioxygenase PIRprobable quercetinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H0K1 | O00625 | |
| Ensembl transtripts involved in fusion gene | ENST00000304987, ENST00000533868, | ENST00000380420, ENST00000380421, ENST00000476381, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SIK2 [Title/Abstract] AND PIR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SIK2 | GO:0006468 | protein phosphorylation | 14976552 |
| Hgene | SIK2 | GO:0035556 | intracellular signal transduction | 14976552 |
| Hgene | SIK2 | GO:0046777 | protein autophosphorylation | 18348280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-G9-6361-01A | SIK2 | chr11 | 111583099 | + | PIR | chrX | 15477863 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000304987 | ENST00000380420 | SIK2 | chr11 | 111583099 | + | PIR | chrX | 15477863 | - |
| In-frame | ENST00000304987 | ENST00000380421 | SIK2 | chr11 | 111583099 | + | PIR | chrX | 15477863 | - |
| 5CDS-5UTR | ENST00000304987 | ENST00000476381 | SIK2 | chr11 | 111583099 | + | PIR | chrX | 15477863 | - |
| intron-3CDS | ENST00000533868 | ENST00000380420 | SIK2 | chr11 | 111583099 | + | PIR | chrX | 15477863 | - |
| intron-3CDS | ENST00000533868 | ENST00000380421 | SIK2 | chr11 | 111583099 | + | PIR | chrX | 15477863 | - |
| intron-5UTR | ENST00000533868 | ENST00000476381 | SIK2 | chr11 | 111583099 | + | PIR | chrX | 15477863 | - |
Top |
FusionProtFeatures for SIK2_PIR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIK2 | PIR |