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Fusion gene ID: 33844 |
FusionGeneSummary for SIK1_HUNK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIK1_HUNK | Fusion gene ID: 33844 | Hgene | Tgene | Gene symbol | SIK1 | HUNK | Gene ID | 150094 | 30811 |
| Gene name | salt inducible kinase 1 | hormonally up-regulated Neu-associated kinase | |
| Synonyms | MSK|SIK|SIK-1|SNF1LK | - | |
| Cytomap | 21q22.3 | 21q22.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase SIK1SNF1-like kinasemyocardial SNF1-like kinasesalt-inducible protein kinase 1serine/threonine-protein kinase SNF1-like kinase 1serine/threonine-protein kinase SNF1LK | hormonally up-regulated neu tumor-associated kinaseB19hormonally upregulated Neu-associated kinasehormonally upregulated neu tumor-associated kinaseserine/threonine protein kinase MAK-V | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P57059 | P57058 | |
| Ensembl transtripts involved in fusion gene | ENST00000270162, | ENST00000270112, ENST00000465574, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SIK1 [Title/Abstract] AND HUNK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SIK1 | GO:0006468 | protein phosphorylation | 14976552 |
| Hgene | SIK1 | GO:0035556 | intracellular signal transduction | 14976552 |
| Hgene | SIK1 | GO:0046777 | protein autophosphorylation | 18348280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CR-7372-01A | SIK1 | chr21 | 44845287 | - | HUNK | chr21 | 33312477 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000270162 | ENST00000270112 | SIK1 | chr21 | 44845287 | - | HUNK | chr21 | 33312477 | + |
| 5CDS-intron | ENST00000270162 | ENST00000465574 | SIK1 | chr21 | 44845287 | - | HUNK | chr21 | 33312477 | + |
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FusionProtFeatures for SIK1_HUNK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIK1 | HUNK |