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Fusion gene ID: 33836 |
FusionGeneSummary for SIAH2_KIAA1430 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIAH2_KIAA1430 | Fusion gene ID: 33836 | Hgene | Tgene | Gene symbol | SIAH2 | KIAA1430 | Gene ID | 6478 | 57587 |
| Gene name | siah E3 ubiquitin protein ligase 2 | cilia and flagella associated protein 97 | |
| Synonyms | hSiah2 | KIAA1430|hmw | |
| Cytomap | 3q25.1 | 4q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase SIAH2RING-type E3 ubiquitin transferase SIAH2seven in absentia homolog 2siah-2 | cilia- and flagella-associated protein 97 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43255 | ||
| Ensembl transtripts involved in fusion gene | ENST00000312960, ENST00000472885, | ENST00000458385, ENST00000514798, ENST00000296775, ENST00000502992, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 3 X 2 X 3=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SIAH2 [Title/Abstract] AND KIAA1430 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A6IW-01A | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000312960 | ENST00000458385 | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
| 5CDS-intron | ENST00000312960 | ENST00000514798 | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
| 5CDS-intron | ENST00000312960 | ENST00000296775 | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
| 5CDS-intron | ENST00000312960 | ENST00000502992 | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
| intron-3CDS | ENST00000472885 | ENST00000458385 | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
| intron-intron | ENST00000472885 | ENST00000514798 | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
| intron-intron | ENST00000472885 | ENST00000296775 | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
| intron-intron | ENST00000472885 | ENST00000502992 | SIAH2 | chr3 | 150480220 | - | KIAA1430 | chr4 | 186085333 | - |
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FusionProtFeatures for SIAH2_KIAA1430 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIAH2 | KIAA1430 |