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Fusion gene ID: 33812 |
FusionGeneSummary for SHROOM3_ASAH1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SHROOM3_ASAH1 | Fusion gene ID: 33812 | Hgene | Tgene | Gene symbol | SHROOM3 | ASAH1 | Gene ID | 57619 | 427 |
| Gene name | shroom family member 3 | N-acylsphingosine amidohydrolase 1 | |
| Synonyms | APXL3|MSTP013|SHRM|ShrmL | AC|ACDase|ASAH|PHP|PHP32|SMAPME | |
| Cytomap | 4q21.1 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein Shroom3F-actin-binding proteinshroom-related protein | acid ceramidaseN-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein | |
| Modification date | 20180523 | 20180529 | |
| UniProtAcc | Q8TF72 | Q13510 | |
| Ensembl transtripts involved in fusion gene | ENST00000296043, ENST00000473602, | ENST00000262097, ENST00000381733, ENST00000417108, ENST00000520781, ENST00000314146, ENST00000520051, | |
| Fusion gene scores | * DoF score | 15 X 11 X 9=1485 | 6 X 6 X 5=180 |
| # samples | 17 | 7 | |
| ** MAII score | log2(17/1485*10)=-3.12685627955043 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SHROOM3 [Title/Abstract] AND ASAH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DB172989 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000296043 | ENST00000262097 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-intron | ENST00000296043 | ENST00000381733 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-intron | ENST00000296043 | ENST00000417108 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-5UTR | ENST00000296043 | ENST00000520781 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-intron | ENST00000296043 | ENST00000314146 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-5UTR | ENST00000296043 | ENST00000520051 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-5UTR | ENST00000473602 | ENST00000262097 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-intron | ENST00000473602 | ENST00000381733 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-intron | ENST00000473602 | ENST00000417108 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-5UTR | ENST00000473602 | ENST00000520781 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-intron | ENST00000473602 | ENST00000314146 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
| intron-5UTR | ENST00000473602 | ENST00000520051 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
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FusionProtFeatures for SHROOM3_ASAH1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SHROOM3 | ASAH1 |