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Fusion gene ID: 33785 |
FusionGeneSummary for SHISA5_IP6K2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SHISA5_IP6K2 | Fusion gene ID: 33785 | Hgene | Tgene | Gene symbol | SHISA5 | IP6K2 | Gene ID | 51246 | 51447 |
| Gene name | shisa family member 5 | inositol hexakisphosphate kinase 2 | |
| Synonyms | SCOTIN | IHPK2|PIUS | |
| Cytomap | 3p21.31 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein shisa-5putative NF-kappa-B-activating protein 120shisa homolog 5 | inositol hexakisphosphate kinase 2ATP:1D-myo-inositol-hexakisphosphate phosphotransferaseinositol hexaphosphate kinase 2insp6 kinase 2pi uptake stimulator | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8N114 | Q9UHH9 | |
| Ensembl transtripts involved in fusion gene | ENST00000296444, ENST00000444115, ENST00000426002, ENST00000465449, ENST00000442747, ENST00000443308, | ENST00000328631, ENST00000340879, ENST00000432678, ENST00000431721, ENST00000449610, ENST00000413298, ENST00000450045, ENST00000446860, ENST00000417896, ENST00000443964, ENST00000436134, ENST00000453202, | |
| Fusion gene scores | * DoF score | 7 X 5 X 4=140 | 5 X 5 X 3=75 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SHISA5 [Title/Abstract] AND IP6K2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IP6K2 | GO:0046854 | phosphatidylinositol phosphorylation | 10574768 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-VS-A8EC-01A | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000296444 | ENST00000328631 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000340879 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000432678 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000431721 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000449610 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000413298 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000450045 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000446860 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000417896 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000443964 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000436134 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000296444 | ENST00000453202 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000328631 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000340879 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000432678 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000431721 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000449610 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000413298 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000450045 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000446860 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000417896 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000443964 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000436134 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000444115 | ENST00000453202 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000328631 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000340879 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000432678 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000431721 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000449610 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000413298 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000450045 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000446860 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000417896 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000443964 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000436134 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000426002 | ENST00000453202 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000328631 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000340879 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000432678 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000431721 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000449610 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000413298 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000450045 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000446860 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000417896 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000443964 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000436134 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000465449 | ENST00000453202 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000328631 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000340879 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000432678 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000431721 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000449610 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000413298 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000450045 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000446860 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000417896 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000443964 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000436134 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| 5CDS-5UTR | ENST00000442747 | ENST00000453202 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000328631 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000340879 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000432678 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000431721 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000449610 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000413298 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000450045 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000446860 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000417896 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000443964 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000436134 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
| intron-5UTR | ENST00000443308 | ENST00000453202 | SHISA5 | chr3 | 48538570 | - | IP6K2 | chr3 | 48732851 | - |
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FusionProtFeatures for SHISA5_IP6K2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SHISA5 | IP6K2 |