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Fusion gene ID: 33773 |
FusionGeneSummary for SHC4_SHC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SHC4_SHC4 | Fusion gene ID: 33773 | Hgene | Tgene | Gene symbol | SHC4 | SHC4 | Gene ID | 399694 | 399694 |
| Gene name | SHC adaptor protein 4 | SHC adaptor protein 4 | |
| Synonyms | RaLP|SHCD | RaLP|SHCD | |
| Cytomap | 15q21.1 | 15q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SHC-transforming protein 4SH2 domain protein C4SHC (Src homology 2 domain containing) family, member 4SHC-transforming protein DhShcDrai-like proteinsrc homology 2 domain-containing-transforming protein C4 | SHC-transforming protein 4SH2 domain protein C4SHC (Src homology 2 domain containing) family, member 4SHC-transforming protein DhShcDrai-like proteinsrc homology 2 domain-containing-transforming protein C4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6S5L8 | Q6S5L8 | |
| Ensembl transtripts involved in fusion gene | ENST00000332408, ENST00000396535, ENST00000537958, | ENST00000332408, ENST00000396535, ENST00000537958, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 3 X 3 X 2=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SHC4 [Title/Abstract] AND SHC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA888309 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000332408 | ENST00000332408 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| intron-intron | ENST00000332408 | ENST00000396535 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| intron-intron | ENST00000332408 | ENST00000537958 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| intron-intron | ENST00000396535 | ENST00000332408 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| intron-intron | ENST00000396535 | ENST00000396535 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| intron-intron | ENST00000396535 | ENST00000537958 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| intron-intron | ENST00000537958 | ENST00000332408 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| intron-intron | ENST00000537958 | ENST00000396535 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
| intron-intron | ENST00000537958 | ENST00000537958 | SHC4 | chr15 | 49171671 | + | SHC4 | chr15 | 49171741 | - |
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FusionProtFeatures for SHC4_SHC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SHC4 | SHC4 |