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Fusion gene ID: 33673 |
FusionGeneSummary for SH3KBP1_VSIG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SH3KBP1_VSIG1 | Fusion gene ID: 33673 | Hgene | Tgene | Gene symbol | SH3KBP1 | VSIG1 | Gene ID | 30011 | 340547 |
| Gene name | SH3 domain containing kinase binding protein 1 | V-set and immunoglobulin domain containing 1 | |
| Synonyms | CD2BP3|CIN85|GIG10|HSB-1|HSB1|MIG18 | 1700062D20Rik|GPA34|dJ889N15.1 | |
| Cytomap | Xp22.12 | Xq22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SH3 domain-containing kinase-binding protein 1CD2-binding protein 3SH3-domain kinase binding protein 1Src family kinase-binding protein 1c-Cbl-interacting proteincbl-interacting protein of 85 kDahuman Src family kinase-binding protein 1migration-in | V-set and immunoglobulin domain-containing protein 1cell surface A33 antigenglycoprotein A34 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96B97 | Q86XK7 | |
| Ensembl transtripts involved in fusion gene | ENST00000397821, ENST00000379716, ENST00000379698, ENST00000541422, ENST00000379697, ENST00000477102, | ENST00000415430, ENST00000217957, ENST00000485533, | |
| Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SH3KBP1 [Title/Abstract] AND VSIG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EE-A2MS-06A | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000397821 | ENST00000415430 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| Frame-shift | ENST00000397821 | ENST00000217957 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| 5CDS-intron | ENST00000397821 | ENST00000485533 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-3CDS | ENST00000379716 | ENST00000415430 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-3CDS | ENST00000379716 | ENST00000217957 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-intron | ENST00000379716 | ENST00000485533 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-3CDS | ENST00000379698 | ENST00000415430 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-3CDS | ENST00000379698 | ENST00000217957 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-intron | ENST00000379698 | ENST00000485533 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-3CDS | ENST00000541422 | ENST00000415430 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-3CDS | ENST00000541422 | ENST00000217957 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-intron | ENST00000541422 | ENST00000485533 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| Frame-shift | ENST00000379697 | ENST00000415430 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| Frame-shift | ENST00000379697 | ENST00000217957 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| 5CDS-intron | ENST00000379697 | ENST00000485533 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-3CDS | ENST00000477102 | ENST00000415430 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-3CDS | ENST00000477102 | ENST00000217957 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
| intron-intron | ENST00000477102 | ENST00000485533 | SH3KBP1 | chrX | 19854243 | - | VSIG1 | chrX | 107301268 | + |
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FusionProtFeatures for SH3KBP1_VSIG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SH3KBP1 | VSIG1 |