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Fusion gene ID: 33629 |
FusionGeneSummary for SH3BGR_IGSF5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SH3BGR_IGSF5 | Fusion gene ID: 33629 | Hgene | Tgene | Gene symbol | SH3BGR | IGSF5 | Gene ID | 6451 | 150084 |
| Gene name | SH3 domain binding glutamate rich protein like | immunoglobulin superfamily member 5 | |
| Synonyms | HEL-S-115|SH3BGR | GSF5|JAM4 | |
| Cytomap | Xq21.1 | 21q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SH3 domain-binding glutamic acid-rich-like proteinSH3 domain binding glutamic acid-rich protein likeSH3-binding domain glutamic acid-rich protein likeepididymis secretory protein Li 115 | immunoglobulin superfamily member 5immunoglobulin superfamily 5 likejunctional adhesion molecule 4 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P55822 | Q9NSI5 | |
| Ensembl transtripts involved in fusion gene | ENST00000380637, ENST00000380634, ENST00000458295, ENST00000380631, ENST00000333634, | ENST00000380588, ENST00000479378, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 2=12 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SH3BGR [Title/Abstract] AND IGSF5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A7-A0CH-01A | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000380637 | ENST00000380588 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| 5CDS-intron | ENST00000380637 | ENST00000479378 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| Frame-shift | ENST00000380634 | ENST00000380588 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| 5CDS-intron | ENST00000380634 | ENST00000479378 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| intron-3CDS | ENST00000458295 | ENST00000380588 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| intron-intron | ENST00000458295 | ENST00000479378 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| Frame-shift | ENST00000380631 | ENST00000380588 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| 5CDS-intron | ENST00000380631 | ENST00000479378 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| Frame-shift | ENST00000333634 | ENST00000380588 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
| 5CDS-intron | ENST00000333634 | ENST00000479378 | SH3BGR | chr21 | 40871841 | + | IGSF5 | chr21 | 41163935 | + |
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FusionProtFeatures for SH3BGR_IGSF5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SH3BGR | IGSF5 |