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Fusion gene ID: 3362 |
FusionGeneSummary for ATP2B4_TFEB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP2B4_TFEB | Fusion gene ID: 3362 | Hgene | Tgene | Gene symbol | ATP2B4 | TFEB | Gene ID | 493 | 7942 |
| Gene name | ATPase plasma membrane Ca2+ transporting 4 | transcription factor EB | |
| Synonyms | ATP2B2|MXRA1|PMCA4|PMCA4b|PMCA4x | ALPHATFEB|BHLHE35|TCFEB | |
| Cytomap | 1q32.1 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plasma membrane calcium-transporting ATPase 4ATPase, Ca++ transporting, plasma membrane 4matrix-remodeling-associated protein 1sarcolemmal calcium pump | transcription factor EBT-cell transcription factor EBclass E basic helix-loop-helix protein 35 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P23634 | P19484 | |
| Ensembl transtripts involved in fusion gene | ENST00000357681, ENST00000391954, ENST00000367218, ENST00000367219, ENST00000341360, ENST00000466407, | ENST00000230323, ENST00000358871, ENST00000420312, ENST00000403298, ENST00000373033, ENST00000394283, | |
| Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 3 X 2 X 3=18 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ATP2B4 [Title/Abstract] AND TFEB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP2B4 | GO:0006874 | cellular calcium ion homeostasis | 19278978 |
| Hgene | ATP2B4 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction | 19278978 |
| Hgene | ATP2B4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19278978 |
| Hgene | ATP2B4 | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 11591728|19278978 |
| Hgene | ATP2B4 | GO:0051001 | negative regulation of nitric-oxide synthase activity | 11591728|17242280|19278978|19287093 |
| Hgene | ATP2B4 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 19287093 |
| Hgene | ATP2B4 | GO:0071872 | cellular response to epinephrine stimulus | 19278978 |
| Hgene | ATP2B4 | GO:0098736 | negative regulation of the force of heart contraction | 17242280 |
| Hgene | ATP2B4 | GO:0140199 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | 17242280 |
| Hgene | ATP2B4 | GO:1900082 | negative regulation of arginine catabolic process | 19278978 |
| Hgene | ATP2B4 | GO:1903249 | negative regulation of citrulline biosynthetic process | 19278978 |
| Hgene | ATP2B4 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity | 19278978 |
| Tgene | TFEB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19556463 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AX-A3G7-01A | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000357681 | ENST00000230323 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000357681 | ENST00000358871 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000357681 | ENST00000420312 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000357681 | ENST00000403298 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000357681 | ENST00000373033 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000357681 | ENST00000394283 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000391954 | ENST00000230323 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000391954 | ENST00000358871 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000391954 | ENST00000420312 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000391954 | ENST00000403298 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000391954 | ENST00000373033 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000391954 | ENST00000394283 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367218 | ENST00000230323 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367218 | ENST00000358871 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367218 | ENST00000420312 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367218 | ENST00000403298 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367218 | ENST00000373033 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367218 | ENST00000394283 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367219 | ENST00000230323 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367219 | ENST00000358871 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367219 | ENST00000420312 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367219 | ENST00000403298 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367219 | ENST00000373033 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000367219 | ENST00000394283 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000341360 | ENST00000230323 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000341360 | ENST00000358871 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000341360 | ENST00000420312 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000341360 | ENST00000403298 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000341360 | ENST00000373033 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 5CDS-5UTR | ENST00000341360 | ENST00000394283 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 3UTR-5UTR | ENST00000466407 | ENST00000230323 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 3UTR-5UTR | ENST00000466407 | ENST00000358871 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 3UTR-5UTR | ENST00000466407 | ENST00000420312 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 3UTR-5UTR | ENST00000466407 | ENST00000403298 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 3UTR-5UTR | ENST00000466407 | ENST00000373033 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
| 3UTR-5UTR | ENST00000466407 | ENST00000394283 | ATP2B4 | chr1 | 203696699 | + | TFEB | chr6 | 41658973 | - |
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FusionProtFeatures for ATP2B4_TFEB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP2B4 | TFEB |