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Fusion gene ID: 33591 |
FusionGeneSummary for SGSH_TBC1D16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SGSH_TBC1D16 | Fusion gene ID: 33591 | Hgene | Tgene | Gene symbol | SGSH | TBC1D16 | Gene ID | 6448 | 125058 |
| Gene name | N-sulfoglucosamine sulfohydrolase | TBC1 domain family member 16 | |
| Synonyms | HSS|MPS3A|SFMD | - | |
| Cytomap | 17q25.3 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-sulphoglucosamine sulphohydrolaseheparan sulfate sulfatasemucopolysaccharidosis type IIIAsulfoglucosamine sulfamidasesulphamidase | TBC1 domain family member 16CTD-2529O21.1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P51688 | Q8TBP0 | |
| Ensembl transtripts involved in fusion gene | ENST00000326317, ENST00000534910, ENST00000570923, ENST00000572208, | ENST00000310924, ENST00000576768, ENST00000340848, ENST00000572862, ENST00000570373, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 2=32 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SGSH [Title/Abstract] AND TBC1D16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SGSH | GO:0006027 | glycosaminoglycan catabolic process | 7493035|15146460 |
| Tgene | TBC1D16 | GO:0001919 | regulation of receptor recycling | 23019362 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-86-7955-01A | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000326317 | ENST00000310924 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-intron | ENST00000326317 | ENST00000576768 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-intron | ENST00000326317 | ENST00000340848 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-intron | ENST00000326317 | ENST00000572862 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-intron | ENST00000326317 | ENST00000570373 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-5UTR | ENST00000534910 | ENST00000310924 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-intron | ENST00000534910 | ENST00000576768 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-intron | ENST00000534910 | ENST00000340848 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-intron | ENST00000534910 | ENST00000572862 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-intron | ENST00000534910 | ENST00000570373 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-5UTR | ENST00000570923 | ENST00000310924 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-intron | ENST00000570923 | ENST00000576768 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-intron | ENST00000570923 | ENST00000340848 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-intron | ENST00000570923 | ENST00000572862 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5CDS-intron | ENST00000570923 | ENST00000570373 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-5UTR | ENST00000572208 | ENST00000310924 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-intron | ENST00000572208 | ENST00000576768 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-intron | ENST00000572208 | ENST00000340848 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-intron | ENST00000572208 | ENST00000572862 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
| 5UTR-intron | ENST00000572208 | ENST00000570373 | SGSH | chr17 | 78190831 | - | TBC1D16 | chr17 | 77987408 | - |
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FusionProtFeatures for SGSH_TBC1D16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SGSH | TBC1D16 |