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Fusion gene ID: 33493 |
FusionGeneSummary for SFN_TYK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SFN_TYK2 | Fusion gene ID: 33493 | Hgene | Tgene | Gene symbol | SFN | TYK2 | Gene ID | 25996 | 7297 |
| Gene name | RNA exonuclease 2 | tyrosine kinase 2 | |
| Synonyms | CGI-114|REX2|RFN|SFN | IMD35|JTK1 | |
| Cytomap | 11q23.2 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | oligoribonuclease, mitochondrialREX2, RNA exonuclease 2 homologRNA exonuclease 2 homologsmall fragment nuclease | non-receptor tyrosine-protein kinase TYK2 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P31947 | P29597 | |
| Ensembl transtripts involved in fusion gene | ENST00000339276, | ENST00000264818, ENST00000524462, ENST00000525621, ENST00000529370, ENST00000529422, | |
| Fusion gene scores | * DoF score | 6 X 1 X 2=12 | 42 X 7 X 17=4998 |
| # samples | 7 | 43 | |
| ** MAII score | log2(7/12*10)=2.54432051622381 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(43/4998*10)=-3.53894233649724 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SFN [Title/Abstract] AND TYK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SFN | GO:0006139 | nucleobase-containing compound metabolic process | 10851236 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-BA-6872-01A | SFN | chr1 | 27190947 | + | TYK2 | chr19 | 10491352 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000339276 | ENST00000264818 | SFN | chr1 | 27190947 | + | TYK2 | chr19 | 10491352 | - |
| 5CDS-intron | ENST00000339276 | ENST00000524462 | SFN | chr1 | 27190947 | + | TYK2 | chr19 | 10491352 | - |
| 5CDS-intron | ENST00000339276 | ENST00000525621 | SFN | chr1 | 27190947 | + | TYK2 | chr19 | 10491352 | - |
| 5CDS-intron | ENST00000339276 | ENST00000529370 | SFN | chr1 | 27190947 | + | TYK2 | chr19 | 10491352 | - |
| 5CDS-intron | ENST00000339276 | ENST00000529422 | SFN | chr1 | 27190947 | + | TYK2 | chr19 | 10491352 | - |
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FusionProtFeatures for SFN_TYK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SFN | TYK2 |