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Fusion gene ID: 33466 |
FusionGeneSummary for SF3B3_NUP88 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SF3B3_NUP88 | Fusion gene ID: 33466 | Hgene | Tgene | Gene symbol | SF3B3 | NUP88 | Gene ID | 23450 | 4927 |
| Gene name | splicing factor 3b subunit 3 | nucleoporin 88 | |
| Synonyms | RSE1|SAP130|SF3b130|STAF130 | - | |
| Cytomap | 16q22.1 | 17p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | splicing factor 3B subunit 3SAP 130pre-mRNA splicing factor SF3b, 130 kDa subunitspliceosome-associated protein 130 | nuclear pore complex protein Nup88karyoporinnuclear pore complex protein 88nucleoporin 88kDanucleoporin Nup88 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15393 | Q99567 | |
| Ensembl transtripts involved in fusion gene | ENST00000302516, | ENST00000573169, ENST00000573584, | |
| Fusion gene scores | * DoF score | 10 X 10 X 7=700 | 3 X 3 X 2=18 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/700*10)=-2.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SF3B3 [Title/Abstract] AND NUP88 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SF3B3 | GO:0000398 | mRNA splicing, via spliceosome | 28781166 |
| Hgene | SF3B3 | GO:0042177 | negative regulation of protein catabolic process | 23951410 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE706779 | SF3B3 | chr16 | 70582572 | - | NUP88 | chr17 | 5319833 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000302516 | ENST00000573169 | SF3B3 | chr16 | 70582572 | - | NUP88 | chr17 | 5319833 | + |
| intron-intron | ENST00000302516 | ENST00000573584 | SF3B3 | chr16 | 70582572 | - | NUP88 | chr17 | 5319833 | + |
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FusionProtFeatures for SF3B3_NUP88 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SF3B3 | NUP88 |