|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 33463 |
FusionGeneSummary for SF3B3_CDH3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SF3B3_CDH3 | Fusion gene ID: 33463 | Hgene | Tgene | Gene symbol | SF3B3 | CDH3 | Gene ID | 23450 | 1013 |
| Gene name | splicing factor 3b subunit 3 | cadherin 15 | |
| Synonyms | RSE1|SAP130|SF3b130|STAF130 | CDH14|CDH3|CDHM|MCAD|MRD3 | |
| Cytomap | 16q22.1 | 16q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | splicing factor 3B subunit 3SAP 130pre-mRNA splicing factor SF3b, 130 kDa subunitspliceosome-associated protein 130 | cadherin-15cadherin 15, type 1, M-cadherin (myotubule)cadherin-14cadherin-3muscle-cadherin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15393 | P22223 | |
| Ensembl transtripts involved in fusion gene | ENST00000302516, | ENST00000264012, ENST00000429102, ENST00000581171, ENST00000569117, | |
| Fusion gene scores | * DoF score | 10 X 10 X 7=700 | 6 X 6 X 4=144 |
| # samples | 12 | 6 | |
| ** MAII score | log2(12/700*10)=-2.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SF3B3 [Title/Abstract] AND CDH3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SF3B3 | GO:0000398 | mRNA splicing, via spliceosome | 28781166 |
| Hgene | SF3B3 | GO:0042177 | negative regulation of protein catabolic process | 23951410 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-44-7667-01A | SF3B3 | chr16 | 70578436 | + | CDH3 | chr16 | 89245824 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000302516 | ENST00000264012 | SF3B3 | chr16 | 70578436 | + | CDH3 | chr16 | 89245824 | + |
| 5CDS-intron | ENST00000302516 | ENST00000429102 | SF3B3 | chr16 | 70578436 | + | CDH3 | chr16 | 89245824 | + |
| 5CDS-intron | ENST00000302516 | ENST00000581171 | SF3B3 | chr16 | 70578436 | + | CDH3 | chr16 | 89245824 | + |
| 5CDS-intron | ENST00000302516 | ENST00000569117 | SF3B3 | chr16 | 70578436 | + | CDH3 | chr16 | 89245824 | + |
Top |
FusionProtFeatures for SF3B3_CDH3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SF3B3 | CDH3 |