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Fusion gene ID: 33451

FusionGeneSummary for SF3B1_SATB2

Fusion gene summary

Fusion gene information	Fusion gene name: SF3B1_SATB2
	Fusion gene ID: 33451
		Hgene	Tgene
	Gene symbol	SF3B1	SATB2
	Gene ID	23451	23314
	Gene name	splicing factor 3b subunit 1	SATB homeobox 2
	Synonyms	Hsh155\|MDS\|PRP10\|PRPF10\|SAP155\|SF3b155	GLSS
	Cytomap	2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	splicing factor 3B subunit 1pre-mRNA processing 10pre-mRNA splicing factor SF3b, 155 kDa subunitspliceosome-associated protein 155splicing factor 3b, subunit 1, 155kDa	DNA-binding protein SATB2SATB family member 2special AT-rich sequence-binding protein 2
	Modification date	20180527	20180523
	UniProtAcc	O75533	Q9UPW6
	Ensembl transtripts involved in fusion gene	ENST00000335508, ENST00000462613, ENST00000409915, ENST00000414963, ENST00000487698,	ENST00000417098, ENST00000443023, ENST00000260926, ENST00000428695, ENST00000457245, ENST00000484124,
Fusion gene scores	* DoF score	5 X 8 X 3=120	3 X 4 X 3=36
	# samples	8	4
	** MAII score	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SF3B1 [Title/Abstract] AND SATB2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SF3B1	GO:0000398	mRNA splicing, via spliceosome	11252167\|28781166

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	STAD	TCGA-VQ-A92D-01A	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000335508	ENST00000417098	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
In-frame	ENST00000335508	ENST00000443023	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
In-frame	ENST00000335508	ENST00000260926	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
In-frame	ENST00000335508	ENST00000428695	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
In-frame	ENST00000335508	ENST00000457245	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
5CDS-intron	ENST00000335508	ENST00000484124	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000462613	ENST00000417098	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000462613	ENST00000443023	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000462613	ENST00000260926	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000462613	ENST00000428695	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000462613	ENST00000457245	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-intron	ENST00000462613	ENST00000484124	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
3UTR-3CDS	ENST00000409915	ENST00000417098	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
3UTR-3CDS	ENST00000409915	ENST00000443023	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
3UTR-3CDS	ENST00000409915	ENST00000260926	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
3UTR-3CDS	ENST00000409915	ENST00000428695	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
3UTR-3CDS	ENST00000409915	ENST00000457245	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
3UTR-intron	ENST00000409915	ENST00000484124	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000414963	ENST00000417098	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000414963	ENST00000443023	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000414963	ENST00000260926	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000414963	ENST00000428695	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000414963	ENST00000457245	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-intron	ENST00000414963	ENST00000484124	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000487698	ENST00000417098	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000487698	ENST00000443023	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000487698	ENST00000260926	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000487698	ENST00000428695	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-3CDS	ENST00000487698	ENST00000457245	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-
intron-intron	ENST00000487698	ENST00000484124	SF3B1	chr2	198283233	-	SATB2	chr2	200173680	-

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FusionProtFeatures for SF3B1_SATB2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SF3B1 O75533	SATB2 Q9UPW6

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Fusion gene ID: 33451

FusionGeneSummary for SF3B1_SATB2

FusionProtFeatures for SF3B1_SATB2