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Fusion gene ID: 33381 |
FusionGeneSummary for SETD3_SETD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SETD3_SETD3 | Fusion gene ID: 33381 | Hgene | Tgene | Gene symbol | SETD3 | SETD3 | Gene ID | 84193 | 84193 |
| Gene name | SET domain containing 3 | SET domain containing 3 | |
| Synonyms | C14orf154 | C14orf154 | |
| Cytomap | 14q32.2 | 14q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase setd3SET domain-containing protein 3 | histone-lysine N-methyltransferase setd3SET domain-containing protein 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86TU7 | Q86TU7 | |
| Ensembl transtripts involved in fusion gene | ENST00000331768, ENST00000329331, ENST00000436070, ENST00000453938, | ENST00000331768, ENST00000329331, ENST00000436070, ENST00000453938, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 2=32 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/1*10)=4.32192809488736 | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SETD3 [Title/Abstract] AND SETD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA094080 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - | ||
| ChiTaRS3.1 | AA090763 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000331768 | ENST00000331768 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000331768 | ENST00000329331 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000331768 | ENST00000436070 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-5UTR | ENST00000331768 | ENST00000453938 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000329331 | ENST00000331768 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000329331 | ENST00000329331 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000329331 | ENST00000436070 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-5UTR | ENST00000329331 | ENST00000453938 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000436070 | ENST00000331768 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000436070 | ENST00000329331 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000436070 | ENST00000436070 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-5UTR | ENST00000436070 | ENST00000453938 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000453938 | ENST00000331768 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000453938 | ENST00000329331 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-3CDS | ENST00000453938 | ENST00000436070 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
| intron-5UTR | ENST00000453938 | ENST00000453938 | SETD3 | chr14 | 99864793 | - | SETD3 | chr14 | 99924762 | - |
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FusionProtFeatures for SETD3_SETD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SETD3 | SETD3 |