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Fusion gene ID: 33341 |
FusionGeneSummary for SESN1_ECHDC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SESN1_ECHDC1 | Fusion gene ID: 33341 | Hgene | Tgene | Gene symbol | SESN1 | ECHDC1 | Gene ID | 27244 | 55862 |
| Gene name | sestrin 1 | ethylmalonyl-CoA decarboxylase 1 | |
| Synonyms | PA26|SEST1 | HEL-S-76|MMCD|dJ351K20.2 | |
| Cytomap | 6q21 | 6q22.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sestrin-1p53 activated gene 26p53 regulated PA26 nuclear protein | ethylmalonyl-CoA decarboxylaseenoyl CoA hydratase domain containing 1enoyl Coenzyme A hydratase domain containing 1enoyl-CoA hydratase domain-containing protein 1epididymis secretory protein Li 76methylmalonyl-CoA decarboxylase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y6P5 | Q9NTX5 | |
| Ensembl transtripts involved in fusion gene | ENST00000436639, ENST00000302071, ENST00000356644, ENST00000517548, | ENST00000454859, ENST00000474289, ENST00000528402, ENST00000454591, ENST00000368291, ENST00000309620, ENST00000430841, ENST00000368289, ENST00000531967, ENST00000488087, | |
| Fusion gene scores | * DoF score | 8 X 3 X 7=168 | 8 X 5 X 5=200 |
| # samples | 8 | 9 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SESN1 [Title/Abstract] AND ECHDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-97-8174-01A | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000436639 | ENST00000454859 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| In-frame | ENST00000436639 | ENST00000474289 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5CDS-3UTR | ENST00000436639 | ENST00000528402 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5CDS-3UTR | ENST00000436639 | ENST00000454591 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5CDS-3UTR | ENST00000436639 | ENST00000368291 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5CDS-3UTR | ENST00000436639 | ENST00000309620 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5CDS-3UTR | ENST00000436639 | ENST00000430841 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5CDS-3UTR | ENST00000436639 | ENST00000368289 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5CDS-3UTR | ENST00000436639 | ENST00000531967 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5CDS-5UTR | ENST00000436639 | ENST00000488087 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3CDS | ENST00000302071 | ENST00000454859 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3CDS | ENST00000302071 | ENST00000474289 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000302071 | ENST00000528402 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000302071 | ENST00000454591 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000302071 | ENST00000368291 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000302071 | ENST00000309620 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000302071 | ENST00000430841 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000302071 | ENST00000368289 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000302071 | ENST00000531967 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-5UTR | ENST00000302071 | ENST00000488087 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3CDS | ENST00000356644 | ENST00000454859 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3CDS | ENST00000356644 | ENST00000474289 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000356644 | ENST00000528402 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000356644 | ENST00000454591 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000356644 | ENST00000368291 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000356644 | ENST00000309620 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000356644 | ENST00000430841 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000356644 | ENST00000368289 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-3UTR | ENST00000356644 | ENST00000531967 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| intron-5UTR | ENST00000356644 | ENST00000488087 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3CDS | ENST00000517548 | ENST00000454859 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3CDS | ENST00000517548 | ENST00000474289 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3UTR | ENST00000517548 | ENST00000528402 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3UTR | ENST00000517548 | ENST00000454591 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3UTR | ENST00000517548 | ENST00000368291 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3UTR | ENST00000517548 | ENST00000309620 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3UTR | ENST00000517548 | ENST00000430841 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3UTR | ENST00000517548 | ENST00000368289 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-3UTR | ENST00000517548 | ENST00000531967 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
| 5UTR-5UTR | ENST00000517548 | ENST00000488087 | SESN1 | chr6 | 109414998 | - | ECHDC1 | chr6 | 127611422 | - |
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FusionProtFeatures for SESN1_ECHDC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SESN1 | ECHDC1 |