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Fusion gene ID: 33340 |
FusionGeneSummary for SESN1_CENPW |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SESN1_CENPW | Fusion gene ID: 33340 | Hgene | Tgene | Gene symbol | SESN1 | CENPW | Gene ID | 27244 | 387103 |
| Gene name | sestrin 1 | centromere protein W | |
| Synonyms | PA26|SEST1 | C6orf173|CENP-W|CUG2 | |
| Cytomap | 6q21 | 6q22.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sestrin-1p53 activated gene 26p53 regulated PA26 nuclear protein | centromere protein Wcancer-up-regulated gene 2 proteincancer-upregulated gene 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y6P5 | Q5EE01 | |
| Ensembl transtripts involved in fusion gene | ENST00000436639, ENST00000302071, ENST00000356644, ENST00000517548, | ENST00000368326, ENST00000368325, ENST00000368328, | |
| Fusion gene scores | * DoF score | 8 X 3 X 7=168 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SESN1 [Title/Abstract] AND CENPW [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-CR-5250-01A | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000436639 | ENST00000368326 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5CDS-intron | ENST00000436639 | ENST00000368325 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5CDS-intron | ENST00000436639 | ENST00000368328 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000302071 | ENST00000368326 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000302071 | ENST00000368325 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000302071 | ENST00000368328 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000356644 | ENST00000368326 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000356644 | ENST00000368325 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| intron-intron | ENST00000356644 | ENST00000368328 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5UTR-intron | ENST00000517548 | ENST00000368326 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5UTR-intron | ENST00000517548 | ENST00000368325 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
| 5UTR-intron | ENST00000517548 | ENST00000368328 | SESN1 | chr6 | 109414998 | - | CENPW | chr6 | 126667351 | + |
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FusionProtFeatures for SESN1_CENPW |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SESN1 | CENPW |