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Fusion gene ID: 33302 |
FusionGeneSummary for SERPINB1_ERRFI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SERPINB1_ERRFI1 | Fusion gene ID: 33302 | Hgene | Tgene | Gene symbol | SERPINB1 | ERRFI1 | Gene ID | 1992 | 54206 |
| Gene name | serpin family B member 1 | ERBB receptor feedback inhibitor 1 | |
| Synonyms | EI|ELANH2|HEL-S-27|HEL57|LEI|M/NEI|MNEI|PI-2|PI2 | GENE-33|MIG-6|MIG6|RALT | |
| Cytomap | 6p25.2 | 1p36.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leukocyte elastase inhibitorepididymis luminal protein 57epididymis secretory protein Li 27peptidase inhibitor 2protease inhibitor 2 (anti-elastase), monocyte/neutrophil derivedserine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 | ERBB receptor feedback inhibitor 1mitogen-inducible gene 6 proteinreceptor-associated late transducer | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P30740 | Q9UJM3 | |
| Ensembl transtripts involved in fusion gene | ENST00000380739, ENST00000537185, ENST00000476896, | ENST00000474874, ENST00000377482, ENST00000467067, ENST00000469499, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 2=32 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SERPINB1 [Title/Abstract] AND ERRFI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ERRFI1 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | 18046415 |
| Tgene | ERRFI1 | GO:0031953 | negative regulation of protein autophosphorylation | 18046415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU620492 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000380739 | ENST00000474874 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-3UTR | ENST00000380739 | ENST00000377482 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-intron | ENST00000380739 | ENST00000467067 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-intron | ENST00000380739 | ENST00000469499 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-intron | ENST00000537185 | ENST00000474874 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-3UTR | ENST00000537185 | ENST00000377482 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-intron | ENST00000537185 | ENST00000467067 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-intron | ENST00000537185 | ENST00000469499 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-intron | ENST00000476896 | ENST00000474874 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-3UTR | ENST00000476896 | ENST00000377482 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-intron | ENST00000476896 | ENST00000467067 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
| intron-intron | ENST00000476896 | ENST00000469499 | SERPINB1 | chr6 | 2833927 | + | ERRFI1 | chr1 | 8072043 | + |
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FusionProtFeatures for SERPINB1_ERRFI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SERPINB1 | ERRFI1 |