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Fusion gene ID: 3326 |
FusionGeneSummary for ATP2A2_ATP2A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP2A2_ATP2A2 | Fusion gene ID: 3326 | Hgene | Tgene | Gene symbol | ATP2A2 | ATP2A2 | Gene ID | 488 | 488 |
| Gene name | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | |
| Synonyms | ATP2B|DAR|DD|SERCA2 | ATP2B|DAR|DD|SERCA2 | |
| Cytomap | 12q24.11 | 12q24.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slow | sarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slow | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P16615 | P16615 | |
| Ensembl transtripts involved in fusion gene | ENST00000308664, ENST00000395494, ENST00000539276, ENST00000550248, ENST00000552636, | ENST00000308664, ENST00000395494, ENST00000539276, ENST00000550248, ENST00000552636, | |
| Fusion gene scores | * DoF score | 12 X 16 X 8=1536 | 8 X 11 X 2=176 |
| # samples | 18 | 12 | |
| ** MAII score | log2(18/1536*10)=-3.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/176*10)=-0.552541023028779 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATP2A2 [Title/Abstract] AND ATP2A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP2A2 | GO:0032469 | endoplasmic reticulum calcium ion homeostasis | 16402920 |
| Hgene | ATP2A2 | GO:0032470 | positive regulation of endoplasmic reticulum calcium ion concentration | 16402920 |
| Hgene | ATP2A2 | GO:0070588 | calcium ion transmembrane transport | 16402920 |
| Hgene | ATP2A2 | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum | 16402920 |
| Tgene | ATP2A2 | GO:0032469 | endoplasmic reticulum calcium ion homeostasis | 16402920 |
| Tgene | ATP2A2 | GO:0032470 | positive regulation of endoplasmic reticulum calcium ion concentration | 16402920 |
| Tgene | ATP2A2 | GO:0070588 | calcium ion transmembrane transport | 16402920 |
| Tgene | ATP2A2 | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum | 16402920 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CV315141 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - | ||
| ChiTaRS3.1 | CB240681 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + | ||
| ChiTaRS3.1 | BF673146 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + | ||
| ChiTaRS3.1 | F00066 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000308664 | ENST00000308664 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000308664 | ENST00000395494 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000308664 | ENST00000539276 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000308664 | ENST00000550248 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000308664 | ENST00000552636 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000395494 | ENST00000308664 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000395494 | ENST00000395494 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000395494 | ENST00000539276 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000395494 | ENST00000550248 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000395494 | ENST00000552636 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000539276 | ENST00000308664 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000539276 | ENST00000395494 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000539276 | ENST00000539276 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000539276 | ENST00000550248 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000539276 | ENST00000552636 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000550248 | ENST00000308664 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000550248 | ENST00000395494 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000550248 | ENST00000539276 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000550248 | ENST00000550248 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000550248 | ENST00000552636 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000552636 | ENST00000308664 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000552636 | ENST00000395494 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000552636 | ENST00000539276 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000552636 | ENST00000550248 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| intron-intron | ENST00000552636 | ENST00000552636 | ATP2A2 | chr12 | 110738529 | - | ATP2A2 | chr12 | 110739189 | - |
| 3UTR-3UTR | ENST00000308664 | ENST00000308664 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-3UTR | ENST00000308664 | ENST00000395494 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-intron | ENST00000308664 | ENST00000539276 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-intron | ENST00000308664 | ENST00000550248 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-intron | ENST00000308664 | ENST00000552636 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-3UTR | ENST00000395494 | ENST00000308664 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-3UTR | ENST00000395494 | ENST00000395494 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-intron | ENST00000395494 | ENST00000539276 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-intron | ENST00000395494 | ENST00000550248 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 3UTR-intron | ENST00000395494 | ENST00000552636 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-3UTR | ENST00000539276 | ENST00000308664 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-3UTR | ENST00000539276 | ENST00000395494 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000539276 | ENST00000539276 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000539276 | ENST00000550248 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000539276 | ENST00000552636 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-3UTR | ENST00000550248 | ENST00000308664 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-3UTR | ENST00000550248 | ENST00000395494 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000550248 | ENST00000539276 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000550248 | ENST00000550248 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000550248 | ENST00000552636 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-3UTR | ENST00000552636 | ENST00000308664 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-3UTR | ENST00000552636 | ENST00000395494 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000552636 | ENST00000539276 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000552636 | ENST00000550248 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| intron-intron | ENST00000552636 | ENST00000552636 | ATP2A2 | chr12 | 110788610 | - | ATP2A2 | chr12 | 110788539 | + |
| 5CDS-intron | ENST00000308664 | ENST00000308664 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-3UTR | ENST00000308664 | ENST00000395494 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000308664 | ENST00000539276 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000308664 | ENST00000550248 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000308664 | ENST00000552636 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000395494 | ENST00000308664 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-3UTR | ENST00000395494 | ENST00000395494 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000395494 | ENST00000539276 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000395494 | ENST00000550248 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000395494 | ENST00000552636 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000539276 | ENST00000308664 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-3UTR | ENST00000539276 | ENST00000395494 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000539276 | ENST00000539276 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000539276 | ENST00000550248 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| 5CDS-intron | ENST00000539276 | ENST00000552636 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-intron | ENST00000550248 | ENST00000308664 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-3UTR | ENST00000550248 | ENST00000395494 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-intron | ENST00000550248 | ENST00000539276 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-intron | ENST00000550248 | ENST00000550248 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-intron | ENST00000550248 | ENST00000552636 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-intron | ENST00000552636 | ENST00000308664 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-3UTR | ENST00000552636 | ENST00000395494 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-intron | ENST00000552636 | ENST00000539276 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-intron | ENST00000552636 | ENST00000550248 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| intron-intron | ENST00000552636 | ENST00000552636 | ATP2A2 | chr12 | 110783892 | - | ATP2A2 | chr12 | 110787709 | + |
| Frame-shift | ENST00000308664 | ENST00000308664 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| Frame-shift | ENST00000308664 | ENST00000395494 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| Frame-shift | ENST00000308664 | ENST00000539276 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| 5CDS-intron | ENST00000308664 | ENST00000550248 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| 5CDS-intron | ENST00000308664 | ENST00000552636 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| Frame-shift | ENST00000395494 | ENST00000308664 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| Frame-shift | ENST00000395494 | ENST00000395494 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| Frame-shift | ENST00000395494 | ENST00000539276 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| 5CDS-intron | ENST00000395494 | ENST00000550248 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| 5CDS-intron | ENST00000395494 | ENST00000552636 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| Frame-shift | ENST00000539276 | ENST00000308664 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| Frame-shift | ENST00000539276 | ENST00000395494 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| Frame-shift | ENST00000539276 | ENST00000539276 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| 5CDS-intron | ENST00000539276 | ENST00000550248 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| 5CDS-intron | ENST00000539276 | ENST00000552636 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-3CDS | ENST00000550248 | ENST00000308664 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-3CDS | ENST00000550248 | ENST00000395494 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-3CDS | ENST00000550248 | ENST00000539276 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-intron | ENST00000550248 | ENST00000550248 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-intron | ENST00000550248 | ENST00000552636 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-3CDS | ENST00000552636 | ENST00000308664 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-3CDS | ENST00000552636 | ENST00000395494 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-3CDS | ENST00000552636 | ENST00000539276 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-intron | ENST00000552636 | ENST00000550248 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
| intron-intron | ENST00000552636 | ENST00000552636 | ATP2A2 | chr12 | 110778520 | + | ATP2A2 | chr12 | 110764242 | + |
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FusionProtFeatures for ATP2A2_ATP2A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP2A2 | ATP2A2 |