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Fusion gene ID: 3321 |
FusionGeneSummary for ATP1B2_SNCB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP1B2_SNCB | Fusion gene ID: 3321 | Hgene | Tgene | Gene symbol | ATP1B2 | SNCB | Gene ID | 482 | 6620 |
| Gene name | ATPase Na+/K+ transporting subunit beta 2 | synuclein beta | |
| Synonyms | AMOG | - | |
| Cytomap | 17p13.1 | 5q35.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium/potassium-transporting ATPase subunit beta-2ATPase, Na+/K+ transporting, beta 2 polypeptideNa, K-ATPase beta-2 polypeptideadhesion molecule in gliaadhesion molecule on gliasodium pump subunit beta-2sodium-potassium ATPase subunit beta 2 (non- | beta-synucleinI(2)-synuclein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P14415 | Q16143 | |
| Ensembl transtripts involved in fusion gene | ENST00000250111, | ENST00000310112, ENST00000393693, ENST00000510387, ENST00000506696, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ATP1B2 [Title/Abstract] AND SNCB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP1B2 | GO:0006883 | cellular sodium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B2 | GO:0010107 | potassium ion import | 10636900|19542013 |
| Hgene | ATP1B2 | GO:0030007 | cellular potassium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B2 | GO:0032781 | positive regulation of ATPase activity | 10636900 |
| Hgene | ATP1B2 | GO:0036376 | sodium ion export across plasma membrane | 10636900|19542013 |
| Hgene | ATP1B2 | GO:0050821 | protein stabilization | 10636900 |
| Hgene | ATP1B2 | GO:0086009 | membrane repolarization | 19542013 |
| Hgene | ATP1B2 | GO:1901018 | positive regulation of potassium ion transmembrane transporter activity | 10636900 |
| Hgene | ATP1B2 | GO:1903278 | positive regulation of sodium ion export across plasma membrane | 10636900 |
| Hgene | ATP1B2 | GO:1903288 | positive regulation of potassium ion import | 10636900 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM702669 | ATP1B2 | chr17 | 7560616 | + | SNCB | chr5 | 176057310 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000250111 | ENST00000310112 | ATP1B2 | chr17 | 7560616 | + | SNCB | chr5 | 176057310 | - |
| 3UTR-5UTR | ENST00000250111 | ENST00000393693 | ATP1B2 | chr17 | 7560616 | + | SNCB | chr5 | 176057310 | - |
| 3UTR-intron | ENST00000250111 | ENST00000510387 | ATP1B2 | chr17 | 7560616 | + | SNCB | chr5 | 176057310 | - |
| 3UTR-intron | ENST00000250111 | ENST00000506696 | ATP1B2 | chr17 | 7560616 | + | SNCB | chr5 | 176057310 | - |
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FusionProtFeatures for ATP1B2_SNCB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP1B2 | SNCB |